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Dysregulation of Lipid Metabolism and Right Ventricular Function in PAH

Pulmonary Arterial Hypertension Clinical Trial

Official title:
Dysregulation of Lipid Metabolism and Right Ventricular Function in PAH

Clinical Trial Summary

Right ventricular (RV) failure is the predominant cause of death in pulmonary arterial hypertension (PAH). No RV-specific therapies are available, in part because the underlying mechanisms of RV dysfunction are poorly understood. Given the heart's preference for fatty acids (FA) as an energy source, a deeper understanding of FA metabolism may shed light on RV adaptation to elevated afterload in PAH. The purpose of this study is to test the hypothesis that defects in fatty acid metabolism are common in PAH and contribute to RV failure. The investigators will measure peripheral and transcardiac lipid and glucose metabolites in PAH patients in comparison with patients with pulmonary venous hypertension and no evidence of pulmonary hypertension. The investigators will also correlate metabolites with concurrent measurement of right ventricular function.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02631421
Study type Observational
Source Vanderbilt University Medical Center
Contact
Status Completed
Phase
Start date January 2015
Completion date June 2019
View Details
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