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Ventricular Reversed Remodeling After LTX in PAH Patients — PAH-LTX  

Pulmonary Arterial Hypertension Clinical Trial

Official title:
Imaging of Ventricular Reversed Remodeling After Double Lung Transplantation in Patients With Pulmonary Arterial Hypertension

Clinical Trial Summary

The investigators will evaluate ventricular reversed remodelling after double lung transplantation (LTX) in patients with pulmonary arterial hypertension (PAH), measured with cardiac magnetic resonance imaging (MRI). Reversed remodelling will be compared with control patients without PAH (e.g. Cystic Fibrosis) who will also undergo LTX.

Clinical Trial Description

In this study, pre-LTX and six-months post-LTX measurements will be compared with each other and between the primary and control group.

Pre- and post-LTX measurements include:

Past medical history: Including basic diagnosis; interventions, surgery and transplant related complications (re-operations, hospitalizations, infections) and medication history; These data will be collected by studying the medical files including surgical reports.

Present medical history: Including NYHA class.

Physical examination: Including length and weight.

Cardiac Magnetic Resonance Imaging:

- Ventricular volume, function and mass measurements

- Flow measurements of the pulmonary artery and aorta

- Disease specific measurements (e.g. septal bowing, RV trabecularisation, etc.)

- T1-mapping

Transthoracic Echocardiography

Resting ECG: Disease specific electrophysiological findings (e.g. QRS-duration, right bundle branch block).

Laboratory evaluation:

- NT-pro-BNP

- eGFR

- Remaining serum will be stored. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02391441
Study type Observational [Patient Registry]
Source University Medical Center Groningen
Contact
Status Completed
Phase
Start date March 2015
Completion date August 2019
View Details
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