Pulmonary Arterial Hypertension Clinical Trial
Official title:
An Open Label Pilot Study of Purified (-)-Epicatechin to Improve Hemodynamics in Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a progressive disease that results in severe
activity limitation and death. There are few treatments for PAH and the available
medications are expensive, difficult to administer and have significant toxicities.
(-)-Epicatechin is a non-toxic compound that naturally occurs in foods such as tea, wine and
chocolate. Clinical intervention studies using dark chocolate in normal volunteers and
subjects at risk for or with established cardiovascular disease have demonstrated
improvements in peripheral and coronary vascular endothelial function, blood pressure,
lipids, glucose tolerance and inflammatory markers.
Our study intends to examine the hemodynamics effects of purified (-)-epicatechin in
subjects with pulmonary arterial hypertension. We hypothesize purified (-)-epicatechin will
reduce pulmonary vascular resistance in patients with pulmonary arterial hypertension.
n/a
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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