Pulmonary Arterial Hypertension Clinical Trial
Official title:
Hemodynamic Evaluation of Patients With Pulmonary Arterial Hypertension. Response to Sildenafil Treatment
The purpose of this study is to determine the clinical, functional and hemodynamic response after six months of sildenafil 50 mg TID in patients with pulmonary arterial hypertension.
Pulmonary arterial hypertension is a chronic devastating disease. There are few approval
oral treatments. Sildenafil, a phosphodiesterase 5 inhibitors, has been recently approved
for patients on functional class II and III showing hemodynamic benefits after 12 weeks of
treatment. Long term hemodynamic evaluation after sildenafil treatment has not been
evaluating in pulmonary arterial patients on functional class II to IV.
The protocol has been designed to evaluate patients on functional class II to IV from
baseline conditions and after 6 months of sildenafil treatment (50 mg po TID). Clinical
(functional class), functional (walked distance-6 minute walking test) and Hemodynamic
evaluation is planned to be performed at baseline and after 6 months of treatment.
;
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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