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Clinical Trial Summary

This project comprises an initial crossover placebo-controlled neurophysiological study to ascertain the effect of acute ketone ester ingestion on motor cortex plasticity, followed by a second 2-week intervention study aimed to compare the effect of a ketogenic diet versus ketone ester supplementation on motor cortex plasticity, resting brain function and structure, and metabolic and neuroendocrine responses.


Clinical Trial Description

The study initially makes a bold attempt to explore whether the ketone supplementation would induce improvements in the overweight/ obese population's brain health via altering motor cortex plasticity, brain function and structure, and metabolic and neuroendocrine pathways. The study's aims include: - assessing changes in brain plasticity associated with excessive body weight and/or obesity. - evaluating the potential of ketone monoester supplementation in enhancing brain plasticity. - evaluating the potential of ketone monoester supplementation in correcting impaired brain plasticity due to excessive body weight. - evaluating the impact of short-term ketogenic dieting and ketone monoester supplementation on brain plasticity. - investigating structural and functional brain adaptations to short-term ketogenic dieting and ketone supplementation. - assessing the relationship between changes in brain plasticity and the brain's structural and functional adaptations and changes in circulating levels of brain-derived neurotrophic factors and key central acting hormones (i.e., insulin and leptin) due to ketogenic dieting and ketone monoester supplementation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT06368297
Study type Interventional
Source University of Macau
Contact Zhaowei Kong, PhD
Phone 8822 8730
Email zwkong@um.edu.mo
Status Not yet recruiting
Phase N/A
Start date April 2024
Completion date August 2024

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