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Psychomotor Agitation clinical trials

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NCT ID: NCT05527314 Completed - Anesthesia, General Clinical Trials

Effect of Remimazolam vs Sevoflurane Anesthesia on Incidence of Emergence Agitation and Complications in Children Undergoing Ophthalmic Surgery

Start date: August 23, 2022
Phase: N/A
Study type: Interventional

As a novel ultra-short-acting benzodiazepines drugs, Remimazolam has been accepted for induction and maintenance of clinical anesthesia. Compared to the traditional benzodiazepines drugs, Remimazolam combines the safety of midazolam with the effectiveness of propofol, and also has the advantages of acting quickly, short half-life, no injection pain, slight respiratory depression, independent of liver and kidney metabolism, long-term infusion without accumulation, and has a specific antagonist: flumazenil. This study aims to investigate whether Remimazolam reduces the incidence of emergence agitation in children after ophthalmic surgery, compared to sevoflurane (RCT).

NCT ID: NCT05451381 Completed - Clinical trials for Hemodynamic Instability

Vasopressor Requirements Depends on Sedation Strategy

Start date: August 1, 2017
Phase: N/A
Study type: Interventional

Most of the patients after cardiac surgery need sedation in the iCU. Sedation strategy could impact the incidence of vasopressor use.

NCT ID: NCT05313659 Completed - Clinical trials for Agitation, Emergence

Intramuscular Ketamine Effect on Postnasal Surgery Agitation

Start date: May 11, 2022
Phase: Phase 2
Study type: Interventional

Emergence agitation (EA) is a common complication after nasal surgery. In this study, we aimed to investigate the effect of intramuscular ketamine on EA following septoplasty and open septorhinoplasty (OSRP) when administered at subanesthetic doses at the end of surgery. Sedation and Agitation scores were recorded using The Richmond agitation-sedation score after extubation.

NCT ID: NCT05272501 Completed - Dementia Clinical Trials

CAlming Touch for People With Agitation or Other Behavioural Symptoms of DEMentia - A Randomized Feasibility Trial

CADEM
Start date: October 4, 2021
Phase: N/A
Study type: Interventional

Dementia is an increasing health challenge among elderly citizens in Denmark. An estimated 87,000 Danes live with dementia, and this number is expected to increase to 130,000 in 2030. Psychiatric symptoms and behavioral changes decrease quality of life for patients and their spouses and is a challenge for caretakers. Behavior changes include agitation which can be divided in four sub-groups: 1) physical aggression, 2) physical non-aggression, 3) verbal aggression, and 4) verbal non-aggression. Pharmaceutical management of behavioral changes is common and may be associated with negative side-effects including drowsiness and falls. Though non-pharmaceutical interventions such as music, massage and social activities have been recommended the underlying evidence is limited. In this randomized feasibility trial, we will investigate the feasibility and acceptability of therapeutic touch aiming to reduce agitated behavior in people living with dementia in a nursing home that specializes in the care of people living with severe dementia. The success criteria of this randomized feasibility trial are as follows: 1. Nursing home residents can be recruited and accept the treatment 'CAlming Touch for People with Agitation or Other Behavioral Symptoms of DEMentia' (CADEM) and complete the feasibility project's test protocol. 2. The treatment concept, which involves the nursing staff in charge of the follow-up treatment, can be implemented in practice. 3. The treatment (CADEM) shows a tendency towards less restless and aggressive behavior for demented citizens evaluated based on a validated measuring tool.

NCT ID: NCT05271552 Completed - Dementia Clinical Trials

Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)

Start date: April 27, 2022
Phase: Phase 3
Study type: Interventional

A study to determine the safety and efficacy of BXCL501 dosing for episodes of agitation associated with dementia when they occur (given as needed [PRN]), for a maximum of 28 doses within a 12-week treatment period.

NCT ID: NCT05261035 Completed - Muscle Disorder Clinical Trials

Stretching Exercises Versus Thermotherapy on Restless Legs Syndrome Symptoms

Exersize
Start date: June 5, 2021
Phase: N/A
Study type: Interventional

To compare the effects of stretching exercises versus thermotherapy on RLS symptoms and sleep quality among pregnant women. Research hypotheses: - Pregnant women who perform leg stretching exercises exhibit lower RLS symptoms severity and pain level than those who applied thermotherapy. - Pregnant women who perform leg stretching exercises exhibit higher sleep quality than those who applied thermotherapy.

NCT ID: NCT05249907 Completed - RLS Clinical Trials

Hemodialysis Patients With Restless Legs Syndrome Used Vibration

Start date: February 7, 2023
Phase: N/A
Study type: Interventional

Restless Legs Syndrome (RLS) is a chronic disorder characterized by abnormal sensations, usually accompanied by pain and restlessness in the legs and/or any part of the body. Sleep quality disorders (10-20%) and limb movements during sleep are quite common in patients with RLS . These disorders in sleep quality are also common among patients receiving hemodialysis due to end-stage renal disease. Pharmacological and non-pharmacological methods are used in the treatment of RLS. Due to the varying success and side effects of pharmacological treatments, non-pharmacological methods have come to the fore for these patients. One of the methods that can be applied as a non-pharmacological method is vibration. The therapeutic effect of instrument-assisted soft tissue manipulation (EYYDM) is not clear, it is stated that it activates the muscles, fascia and tendon and improves pain clinically in studies. The aim of the study is to determine the most effective treatment method on pain and sleep quality by comparing the effects of vibration and EYYDM methods in dialysis patients with restless legs syndrome

NCT ID: NCT05223010 Completed - Emergence Agitation Clinical Trials

Melatonin for Pediatric Emergence Agitation

Start date: January 30, 2022
Phase: Phase 4
Study type: Interventional

efficacy of melatonin premedication on emergence agitation in children undergoing herniorrhaphy surgeries

NCT ID: NCT05214963 Completed - Clinical trials for Restless Legs Syndrome

Noninvasive Peripheral Nerve Stimulation for Medication-Naive and Medication-Refractory RLS

Start date: March 8, 2022
Phase: N/A
Study type: Interventional

Prospective multi-site randomized sham-controlled study evaluating tolerability and efficacy of noninvasive peripheral nerve stimulation (NPNS) for patients with moderate-severe primary Restless Legs Syndrome (RLS) who are either medication-naive or medication-refractory.

NCT ID: NCT05196828 Completed - Clinical trials for Restless Legs Syndrome

Extension Study Evaluating NTX100 Neuromodulation System for Medication-Refractory Primary RLS

Start date: December 20, 2021
Phase: N/A
Study type: Interventional

Multi-center, prospective open-label extension study of noninvasive peripheral nerve stimulation (NPNS) with the NTX100 Neuromodulation System for patients with medication-refractory moderate- severe primary RLS