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Psychomotor Agitation clinical trials

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NCT ID: NCT05313659 Completed - Clinical trials for Agitation, Emergence

Intramuscular Ketamine Effect on Postnasal Surgery Agitation

Start date: May 11, 2022
Phase: Phase 2
Study type: Interventional

Emergence agitation (EA) is a common complication after nasal surgery. In this study, we aimed to investigate the effect of intramuscular ketamine on EA following septoplasty and open septorhinoplasty (OSRP) when administered at subanesthetic doses at the end of surgery. Sedation and Agitation scores were recorded using The Richmond agitation-sedation score after extubation.

NCT ID: NCT05272501 Completed - Dementia Clinical Trials

CAlming Touch for People With Agitation or Other Behavioural Symptoms of DEMentia - A Randomized Feasibility Trial

CADEM
Start date: October 4, 2021
Phase: N/A
Study type: Interventional

Dementia is an increasing health challenge among elderly citizens in Denmark. An estimated 87,000 Danes live with dementia, and this number is expected to increase to 130,000 in 2030. Psychiatric symptoms and behavioral changes decrease quality of life for patients and their spouses and is a challenge for caretakers. Behavior changes include agitation which can be divided in four sub-groups: 1) physical aggression, 2) physical non-aggression, 3) verbal aggression, and 4) verbal non-aggression. Pharmaceutical management of behavioral changes is common and may be associated with negative side-effects including drowsiness and falls. Though non-pharmaceutical interventions such as music, massage and social activities have been recommended the underlying evidence is limited. In this randomized feasibility trial, we will investigate the feasibility and acceptability of therapeutic touch aiming to reduce agitated behavior in people living with dementia in a nursing home that specializes in the care of people living with severe dementia. The success criteria of this randomized feasibility trial are as follows: 1. Nursing home residents can be recruited and accept the treatment 'CAlming Touch for People with Agitation or Other Behavioral Symptoms of DEMentia' (CADEM) and complete the feasibility project's test protocol. 2. The treatment concept, which involves the nursing staff in charge of the follow-up treatment, can be implemented in practice. 3. The treatment (CADEM) shows a tendency towards less restless and aggressive behavior for demented citizens evaluated based on a validated measuring tool.

NCT ID: NCT05271552 Completed - Dementia Clinical Trials

Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)

Start date: April 27, 2022
Phase: Phase 3
Study type: Interventional

A study to determine the safety and efficacy of BXCL501 dosing for episodes of agitation associated with dementia when they occur (given as needed [PRN]), for a maximum of 28 doses within a 12-week treatment period.

NCT ID: NCT05261035 Completed - Muscle Disorder Clinical Trials

Stretching Exercises Versus Thermotherapy on Restless Legs Syndrome Symptoms

Exersize
Start date: June 5, 2021
Phase: N/A
Study type: Interventional

To compare the effects of stretching exercises versus thermotherapy on RLS symptoms and sleep quality among pregnant women. Research hypotheses: - Pregnant women who perform leg stretching exercises exhibit lower RLS symptoms severity and pain level than those who applied thermotherapy. - Pregnant women who perform leg stretching exercises exhibit higher sleep quality than those who applied thermotherapy.

NCT ID: NCT05249907 Completed - RLS Clinical Trials

Hemodialysis Patients With Restless Legs Syndrome Used Vibration

Start date: February 7, 2023
Phase: N/A
Study type: Interventional

Restless Legs Syndrome (RLS) is a chronic disorder characterized by abnormal sensations, usually accompanied by pain and restlessness in the legs and/or any part of the body. Sleep quality disorders (10-20%) and limb movements during sleep are quite common in patients with RLS . These disorders in sleep quality are also common among patients receiving hemodialysis due to end-stage renal disease. Pharmacological and non-pharmacological methods are used in the treatment of RLS. Due to the varying success and side effects of pharmacological treatments, non-pharmacological methods have come to the fore for these patients. One of the methods that can be applied as a non-pharmacological method is vibration. The therapeutic effect of instrument-assisted soft tissue manipulation (EYYDM) is not clear, it is stated that it activates the muscles, fascia and tendon and improves pain clinically in studies. The aim of the study is to determine the most effective treatment method on pain and sleep quality by comparing the effects of vibration and EYYDM methods in dialysis patients with restless legs syndrome

NCT ID: NCT05223010 Completed - Emergence Agitation Clinical Trials

Melatonin for Pediatric Emergence Agitation

Start date: January 30, 2022
Phase: Phase 4
Study type: Interventional

efficacy of melatonin premedication on emergence agitation in children undergoing herniorrhaphy surgeries

NCT ID: NCT05214963 Completed - Clinical trials for Restless Legs Syndrome

Noninvasive Peripheral Nerve Stimulation for Medication-Naive and Medication-Refractory RLS

Start date: March 8, 2022
Phase: N/A
Study type: Interventional

Prospective multi-site randomized sham-controlled study evaluating tolerability and efficacy of noninvasive peripheral nerve stimulation (NPNS) for patients with moderate-severe primary Restless Legs Syndrome (RLS) who are either medication-naive or medication-refractory.

NCT ID: NCT05196828 Completed - Clinical trials for Restless Legs Syndrome

Extension Study Evaluating NTX100 Neuromodulation System for Medication-Refractory Primary RLS

Start date: December 20, 2021
Phase: N/A
Study type: Interventional

Multi-center, prospective open-label extension study of noninvasive peripheral nerve stimulation (NPNS) with the NTX100 Neuromodulation System for patients with medication-refractory moderate- severe primary RLS

NCT ID: NCT05176119 Completed - Pediatric ALL Clinical Trials

Nalbuphine Versus Ketamine for Prevention of Emergence Agitation After Sevoflurane in Children Undergoing Tonsillectomy

Start date: March 25, 2021
Phase: Phase 4
Study type: Interventional

The effect of low dose nalbuphine or ketamine in the prevention of emergence agitation after sevoflurane anesthesia in children undergoing tonsillectomy with or without adenoidectomy. This randomized double-blind study was carried out at, Ain shams University Hospitals, from March 2021 to June 2021 on 90 patients after approval of the ethical committee.

NCT ID: NCT05165914 Completed - Agitation Clinical Trials

Midazolam Effect on Agitation Postnasal Surgery

Start date: May 27, 2021
Phase: N/A
Study type: Interventional

Postoperative agitation is a common complication, it's incidence post head and neck surgery is around 11-26%. Avoiding such complication is mandatory to facilitate patient's recovery and reduce risk of postoperative agitation related complications. Our study aims to detect the incidence of agitation following nasal surgery, and to determine the midazolam effect on agitation, when administered just before emergence from anesthesia.