Identifying the Neural Basis of Capability for Suicide

Major Depressive Disorder Clinical Trial

Official title: Identifying the Neural Basis of Capability for Suicide

Status Recruiting

Clinical Trial Summary

Since capability for suicide involves overriding potential pain, and the opioid system plays a strong role in controlling pain perception, it follows that capability for suicide may be impacted by the opioid system. The goal of the proposed research is to identify the neural network underlying capability for suicide in order to determine if it can be a target for identifying high-risk individuals and for intervention.

Clinical Trial Description

Little evidence exists distinguishing individuals with suicidal ideation (SI) from those at risk for suicidal behaviour, illustrating the need for more comprehensive biomarkers for clinicians to guide their treatment approach and for new treatment avenues. Current theories of suicide have suggested the importance of an individual's capability for suicide in predicting suicide attempt or death. Building on this, Yovell and colleagues (2016) provided important preliminary data that the opioid system affects suicide risk, but the neural mechanisms and their relationship to capability for suicide are unclear. The goal of the proposed research is to identify the neural network underlying capability for suicide using functional magnetic resonance imaging (fMRI) in order to determine if it can be a target for identifying high-risk individuals and for intervention. ;

Related Conditions & MeSH terms

• Depressive Disorder
• Depressive Disorder, Major
• Major Depressive Disorder
• Mental Disorders
• Psychiatric Illness
• Suicidal Ideation
• Suicide

• NCT number: NCT03327129
• Study type: Observational
• Source: Unity Health Toronto
• Contact: Hailey Wright, B.Arts. Sc
• Phone: 4168646060
• Email: Hailey.Wright@unityhealth.to
• Status: Recruiting
• Start date: January 1, 2023
• Completion date: September 2024