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NCT03265457 Clinical Trial

The Endothelial Count in Pxf

Pseudoexfoliation Syndrome Clinical Trial

Official title:
The Corneal Endothelial Cell Count in Eyes With Pseudoexfoliation Syndrome

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT03265457
Other study ID # PXF
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date October 1, 2018
Est. completion date October 1, 2020

Study information
Verified date June 2018
Source Assiut University
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Pseudoexfoliation Syndrome Is a common disorder in Egypt. IT is one of the common causes of coexisting cataract and glaucoma. It may be associated with a less than normal endothelial count.

Description:

The corneal Endothelium is essential for the maintenance of normal corneal hydration, thickness, and transparency.

In patients with pseudoexfoliation syndrome , quantitative and qualitative morphological changes of the corneal endothelium have been demonstrated in specular and electron microscopic studies.

Specular microscopy is a non-invasive technique to access the structure and function of the corneal endothelium.

Our research question is to study Endothelial cell count in patients with pseudoexfoliation syndrome & compare it to age matched group.

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 20
Est. completion date October 1, 2020
Est. primary completion date October 1, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group N/A and older
Eligibility Inclusion Criteria:

- Patients with pseudoexfoliation syndrome

Exclusion Criteria:

- Patients with previous intra ocular surgeries.

- Patients with uveitis

- Patients with fuck's endothelial dystrophy

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• Specular microscopy
Comparison between corneal Endothelial count in patients with pseudoexfoliation syndrome and age matched group

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

References & Publications (1)

Miyake K, Matsuda M, Inaba M. Corneal endothelial changes in pseudoexfoliation syndrome. Am J Ophthalmol. 1989 Jul 15;108(1):49-52. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary Comparison between endothelial cell count in patients with Pseudoexfoliation syndrome and age matched controls. The corneal Endothelial cell count in patients with pseudoexfoliation syndrome will be measured by the specular microscopy & compared with the normal endothelial count in people at the same group One year
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Completed NCT03453827 - Long-term Intraocular Lens (IOL) Decentration and Tilt in Eyes With Pseudoexfoliation Syndrome (PES) Following Cataract Surgery N/A