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Effects of High-concentration Topical Capsaicin on Histaminergic and Non-histaminergic Itch

Pruritus Clinical Trial

Official title:
The Role of Pre-established Skin Inflammation on the Susceptibility to Histamine and Cowhage-induced Itch in Healthy Humans

Clinical Trial Summary

The purpose of this project is to investigate the effect of capsaicin-induced neurogenic inflammation with three different intensities on itch subsequently induced by histamine and cowhage. The hypothesis is that capsaicin-induced pre-established neurogenic inflammation significantly increases susceptibility to itch provocations with cowhage and histamine.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02769910
Study type Interventional
Source Aalborg University
Contact
Status Completed
Phase Phase 1/Phase 2
Start date May 2016
Completion date July 2016
View Details
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