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Proteomics clinical trials

View clinical trials related to Proteomics.

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NCT ID: NCT03096535 Completed - Obesity Clinical Trials

Cold Induced Activation of Brown Adipose Tissue in Humans

COLDBAT
Start date: April 2, 2017
Phase: N/A
Study type: Interventional

This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days. A secondary purpose is to make a validation of an infrared thermography camera by comparison of skin temperatures and SUV of the supraclavicular brown adipose tissue.

NCT ID: NCT03095846 Completed - Type2 Diabetes Clinical Trials

Cold Induced Activation of Brown Adipose Tissue in Winter Swimmers

COLDBAT_WS
Start date: April 2, 2017
Phase: N/A
Study type: Interventional

This study investigates cold-induced brown fat activation in winter swimmers and not-winter swimmers by skin temperature measures assessed with infra red thermography imaging and skin temperatures. Winter swimmers and not-winter swimmers will participate in an acute cooling intervention and thermoneutral intervention for comparison of energy expenditure and skin temperatures at the supraclavicular area.

NCT ID: NCT03043365 Completed - Proteomics Clinical Trials

Effect of Fish Oil Enriched In Omega-11 Fatty Acid On Lipoprotein Metabolism In Adults

Start date: June 15, 2017
Phase: Phase 2
Study type: Interventional

Background: Fish oils are known to be beneficial to health and believed to be cardio-protective. Omega-3 fatty acid is the most known fish oil available in the market. LCMUFA (long-chain monounsaturated fatty acids) is also a fish oil but it is derived from fish that consumes a diet rich in omega-11 fatty acid. Researchers want to study omega-11 fatty acid enriched fish oil and understand its effect on cardiovascular health. Objective: To understand the effects of LCMUFA from fish oil on cardiovascular health. Eligibility: Healthy volunteers ages 18 and older with no history of cardiovascular disease Design: Participants will be screened with: - Medical history - Physical exam - Fasting blood and urine tests - Optional stool sample - Questions about their diet, exercise, and the types of medicines and dietary supplements they take - 7-day food diary - Cardio-Ankle Vascular Index (CAVI): Blood pressure is taken in the arms and legs. The heart is monitored. - After the screening visit, participants will take 4 gel capsules, 3 times a day after meals, for 8-10 weeks. - Electrocardiogram (EKG) Participants will have 3 additional visits. All include repeats of the screening tests. Visit 2 is 8 weeks after the screening visit. Participants will stop taking the capsules for 8 weeks after this visit. Visit 3 is at least 16 weeks after starting the supplement. Participants will take 4 capsules, 3 times a day after meals, for 8 weeks after this visit. Visit 4 is 8 weeks after starting the second supplement.

NCT ID: NCT02514070 Completed - Proteomics Clinical Trials

Comparison of EPA and DHA-Rich Fish Oils on Lipoprotein Metabolism In Adults

Start date: October 30, 2015
Phase: Phase 2
Study type: Interventional

Background: - Metabolism is what the body does to turn food into energy. Omega-3 fatty acids are substances found in foods such as cold-water fish and shellfish that are essential for good health. Researchers want to see the effect of two fatty acids eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on metabolism. They may be beneficial to cardiovascular health. Objective: - To understand the effects of EPA and DHA on metabolism. Eligibility: - Healthy people ages 18 years or above with plasma triglyceride (a type of fat in the blood) levels of 100 mg/dL or higher Design: - The study will last 20 to 24 weeks. - Participants will have 4 visits to the NIH Clinical Center. These will include: - Medical history - Physical Fasting blood and urine tests - CAVI tests: blood pressure is taken in the arms and legs, and the heart is monitored. - Participants will take an EPA/DHA dietary supplement. They will take 4 gel capsules, 3 times a day, for 6 or 7 weeks. Then they will not take the capsules for 8 to 10 weeks (a wash-out period). They will then take the capsules again for 6 or 7 weeks. - Participants will keep a food journal.

NCT ID: NCT01151917 Completed - Insulin Resistance Clinical Trials

Proteomics in Morbid Obesity After Bariatric Surgery

PROTOBESE
Start date: June 2009
Phase: N/A
Study type: Observational

Glycemic control is rapidly restored in patients with insulin resistance after bariatric surgery, in particular after the mal-absorptive one (i.e. Bilio-pancreatic diversion, BPD). To evaluate the mechanisms allowing restoration of insulin sensitivity after BPD the investigators aimed at identifying by using a proteomic approach plasma proteins or peptides that may be involved in the remarkably fast and explicit restoration of insulin sensitivity. In addition to the unbiased proteomics approach, a selection of recognized markers for metabolic control will be measured. These efforts all aim at an increased understanding of how insulin sensitivity is regulated and may provide novel ideas of how to treat insulin resistance and type 2-diabetes.

NCT ID: NCT00397436 Active, not recruiting - Proteomics Clinical Trials

Pilot Study of Protein Profiling of the Human Epidermal Cells After Ultraviolet Irradiation

Start date: February 2007
Phase: Phase 0
Study type: Interventional

The main focus of this pilot study is to construct a fairly complete protein profile of the epidermis. This will allow us to study how the epidermis responds to external stressors such as ultra-violet. We hypothesize that by using the cutting edge technology, proteomics, we will be able to construct a fairly complete profile of different epidermal cells (keratinocytes, epidermal nerve fibers (ENFs), melanocytes, Langerhans cell,...etc) of normal and ultraviolet (UV) irradiated skin.