Obesity Clinical Trial
Official title:
Cold Induced Activation of Brown Fat in Humans Assessed With PET/MR Scans and Skin-temperature Measure - A Cross-over Randomized Controlled Trial.
This study investigates cold-induced brown fat activation assessed using PET/MR scans. Subjects will participate in an acute cooling intervention day and a thermoneutral intervention day with PET/MR scans on both days. A secondary purpose is to make a validation of an infrared thermography camera by comparison of skin temperatures and SUV of the supraclavicular brown adipose tissue.
The field of human brown adipose tissue (BAT) research is focused on activation of BAT as a
means of manipulating energy expenditure and potentially anti-obesity and anti-diabetic
properties of the tissue. This is well established in rodent studies and explained as due to
the specific brown fat uncoupling protein 1 (UCP1). Despite increasing evidence that
indicates a metabolic regulatory role of BAT in humans, BAT activation/recruitment is not
fully understood and even less is known about the endocrine capacities of human BAT.
Cold induced brown fat activity will be assessed with PET/MR scans and validate an infra-red
thermography camera, as well as perform a proteomic screening using blood samples under these
two intervention days.
15 healthy lean male subjects will serve as their own control in a cross-over randomized
control study, including a pre-examination day, a thermoneutral-day and a cooling test-day
with cold exposure followed by a PET/MR scan to determine BAT activity. An extra cooling day
is applied for the external validation of the infrared thermography camera. Blood samples and
abdominal fat-biopsies will be taken at thermoneutral condition and under cold stimulation of
brown fat.
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