The Impact of Anxiety or Depression on the Sedative Concentration of

Status Completed

Clinical Trial Summary

Clinical Trial Description

120 consecutive female patients, 18-65 years old, American Society of Anesthesiologists ( ASA) physical status I to II, scheduled for hysteroscopic surgery under propofol-based intravenous anesthesia will be recruited in this prospective cohort study. The day before surgery, participants were asked to complete the modified HADS questionnaire in an isolated calm room, and the score was used to assess the patients' anxiety and depression level in the past 6 months. On the day of surgery, propofol (Fresenius Kabi Austria GmbH, Graz, Austria)was administrated by using an intravenous target controlled infusion (TCI) pump (Alaris PK, Basingstoke, UK) with Schnider kinetic model. The initial effect-site concentration (Ce) was set as 1.0 μg/ml. After the TCI system displayed that Cp and Ce were at equilibrium, the target concentration of propofol was increased by an increment of 0.5 μg/ml until the patients achieved the three desired levels of sedation.The Ce and dose of propofol and the consuming time were recorded. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03741361
Study type	Observational
Source	First Affiliated Hospital, Sun Yat-Sen University
Contact
Status	Completed
Phase
Start date	November 27, 2018
Completion date	February 15, 2019

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The Impact of Anxiety or Depression on the Sedative Concentration of Propofol

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms