Predictive Value of Combining AccuIMR and AccuFFR in Patients With STEMI

Prognosis Clinical Trial

Official title:

Predictive Value of Combining Angio-Based Index of Microcirculatory Resistance and Fractional Flow Reserve in Patients With STEMI

Clinical Trial Details — Status: Active, not recruiting

Administrative data

• NCT number: NCT06435728
• Other study ID #: D2023173
• Status: Active, not recruiting
• Start date: March 1, 2024
• Est. completion date: May 30, 2024

Study information

• Verified date: May 2024
• Source: Peking University Third Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Patients with acute myocardial infarction were enrolled retrospectively. The fractional flow reserve (AccuFFR) and microcirculatory resistance index (AccuIMR) based on coronary angiography were analyzed, and the relationship between FFR and IMR and the prognosis of patients with acute myocardial infarction was analyzed

Description:

We retrospectively enrolled STEMI patients who underwent PCI in Peking University Third Hospital. The fractional flow reserve (AccuFFR) and microcirculatory resistance index (AccuIMR) based on coronary angiography were obtained by analyzing the coronary angiography images. The prognosis of patients was obtained by searching inpatient and outpatient systems and telephone follow-up. The relationship between AccuFFR, AccuIMR and prognosis was statistically analyzed

Recruitment information / eligibility

• Status: Active, not recruiting
• Enrollment: 1297
• Est. completion date: May 30, 2024
• Est. primary completion date: April 30, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Age of >18 years;

• Onset-to-treatment time of =12 h, meeting the diagnostic criteria for STEMI;

• underwent primary PCI within 12 h of symptom onset and achieved successful PCI in the culprit vessel;

• Availability of complete clinical data

Exclusion Criteria:

• severe tortuosity and overlap of the target vessel;

• poor-quality coronary angiography images;

• missing two coronary angiography images >25° apart

Related Conditions & MeSH terms

• Acute ST Segment Elevation Myocardial Infarction
• Infarction
• Myocardial Infarction
• Prognosis
• ST Elevation Myocardial Infarction

Intervention

Diagnostic Test:
• AccuIMR and AccuFFR
AccuFFR and AccuIMR were obtained by reviewing coronary angiography at the time of primary PCI

Locations

Country	Name	City	State
China	Peking University Third Hospital	Beijing

Sponsors (1)

Lead Sponsor	Collaborator
Peking University Third Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	MACE	cardiovascular death, all-cause death, readmission for heart failure (HF), and recurrent coronary events	3 years after myocardial infarction
Secondary	recurrent coronary events	nonfatal myocardial infarction, unplanned PCI, and unplanned coronary artery bypass grafting	3 years after myocardial infarction