Prognosis Clinical Trial
Official title:
Hemoglobin, Neutrophil to Lymphocyte Ratio and Platelet Count Improve Prognosis Prediction of TNM Staging System in Nasopharyngeal Carcinoma: A Prospective Multi-institutional Observation Study
RATIONALE
1. In patients with nasopharyngeal carcinoma, there is sometimes a discrepancy between
actual clinical outcome and TNM stages because it is an anatomy-based system in which
functional factors are not concerned.
2. Hemoglobin, neutrophil to lymphocyte ratio and platelet count were proved to improve
prognosis prediction of TNM staging system in our previous retrospective study.
PURPOSE To validate that the prognostic index based on complete blood count and TNM system
had higher prediction efficiency on survival in nasopharyngeal carcinoma than TNM system
alone.
Totally 720 patients with non-metastatic nasopharyngeal carcinoma will be include and will be divided into 3 groups (Low Risk, Intermediate Risk and High Risk Groups) according to their prognostic index, which is on basis of blood cell count indexes and TNM stage. The 3 groups of patients will undergo a radical radiotherapy or chemoradiotherapy and be followed until death or the end of the study. Comparison on survivals of the 3 groups will be made to validate the accuracy of the prognostic index. And comparison on prediction efficacy between prognostic index and TNM staging system will be made. ;
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