Probiotics Clinical Trial
Official title:
Effect of Probiotic Supplementation on Exercise Metabolism During Exercise in the Heat and Subsequent Effect on Gastrointestinal Disturbance and Gut Microbiome Composition
Endurance athletes will be invited to participate in the following study. Subjects will visit the laboratory on three occasions, each time following an overnight fast. Briefly, following an initial assessment and familiarisation, participants will be required to complete an endurance bout of cycling exercise in hot environmental conditions before and after 4 weeks of supplementing with a probiotic or placebo. During the exercise bouts, breath samples will be collected for measurements of whole-body metabolism, blood samples will be collected to assess serum metabolites and markers of gastrointestinal (GI) damage, and subjective measures of effort and symptoms of GI thermal distress will be collected. Before and after each exercise bout, participants will be required to provide a faecal sample for analysis of the microbiome and GI inflammation
Status | Recruiting |
Enrollment | 20 |
Est. completion date | April 10, 2023 |
Est. primary completion date | April 10, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Training/competing in exercise/sport for a minimum of 4 hours per week Exclusion Criteria: - Free from current illness - No history of diabetes, high cholesterol, uncontrolled asthma or history of heart disease - Free from current musculoskeletal injury - No history of and free from GI related clinical conditions (IBS, Chron's Disease) - Not currently taking NSAIDs/Antihistamines/Immunosuppressive drugs - Without history of gastric ulcers or other gastric problems - Free from habitual use of NSAIDs i.e. 2 x per week for previous 1 month - Have no allergy or intolerance to standardised meal foods or be adherent to kosher diet |
Country | Name | City | State |
---|---|---|---|
United Kingdom | Liverpool John Moores University, Tom Reilly Building, Byrom Street Campus | Liverpool | Merseyside |
Lead Sponsor | Collaborator |
---|---|
Liverpool John Moores University |
United Kingdom,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in Gastro-Intestinal Disturbance Following Probiotic Supplementation | Subjective assessment of GI discomfort experienced during cycling effort in the heat pre- and post- 4-week probiotic supplementation | 4 weeks | |
Primary | Change in Exogenous Glucose-Fructose Oxidation Following Probiotic Supplementation | During exercise carbohydrate will be administered and the uptake and utilization of this will be measured via gas analysis of breath, tracer detection will be compared pre- and post- 4-week probiotic supplementation. | 4 weeks | |
Secondary | Change in time to exhaustion after 180 mins cycling exercise in the heat following probiotic supplementation | Participants will cycle at a wattage on the bike that is high enough to induce fatigue, they will cycle at this wattage until failure (inability to keep the pedals turning/voluntary stoppage). This will be compared pre- and post- 4-week probiotic supplementation. | 4 weeks | |
Secondary | Change in circulatory metabolites during exercise following probiotic supplementation | Glucose will be measured during exercise, this will be compared pre- and post- 4-week probiotic supplementation. | 4 weeks | |
Secondary | Change in circulatory metabolites during exercise following probiotic supplementation | Lactate will be measured during exercise, this will be compared pre- and post- 4-week probiotic supplementation. | 4 weeks | |
Secondary | Change in circulatory metabolites during exercise following probiotic supplementation | Insulin will be measured during exercise, this will be compared pre- and post- 4-week probiotic supplementation. | 4 weeks | |
Secondary | Change in circulatory metabolites during exercise following probiotic supplementation | Non-esterified fatty acids will be measured during exercise, this will be compared pre- and post- 4-week probiotic supplementation. | 4 weeks | |
Secondary | Change in circulatory metabolites during exercise following probiotic supplementation | Glycerol will be measured during exercise, this will be compared pre- and post- 4-week probiotic supplementation. | 4 weeks |
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