Adjunctive Probiotics in Chronic Periodontitis

Status Completed

Clinical Trial Summary

This study will assess clinical and microbiological efficacy of probiotics and antibiotics in patients of chronic periodontitis as an adjunctive to scaling and root planing (SRP) in reducing bacterial count and in improving clinical periodontal parameters over the period of 12 weeks.Also the comparison between these adjunctives will be made for clinical assessment clinical periodontal parameters will be taken .these parameters plaque index (PI), gingival index (GI), clinical attachment loss (CAL) and pocket probing depth (PPD) for microbiological assessment plaque sample will be taken, DNA will be extracted and then sample will be processed through quantitative polymerase chain reaction (qPCR) for quantitative analysis of bacterial count of porphyromonas gingivalis.

Clinical Trial Description

In this clinical trial total 60 participants of clinically diagnosed chronic periodontitis will be recruited after taking a written consent for their approval. Participants will be divided into 3 groups A, B and C through the process of randomization using a method of opaque sealed envelopes. A research assistant will be hired for the purpose of randomization and allocation concealment. All participants will be asked to pick an opaque envelope containing the details of treatment products. After randomization plaque sample will be obtained from the depth of periodontal pockets and all the clinical periodontal parameters will be recorded in every participant. Then all the participants will undergo SRP. After SRP group A will be given antibiotics Amoxicillin 500 milligrams (mg) for 3 times a day (TDS) and Metronidazole 400 milligrams (mg) for twice a day (BD) for 5 days. Group B will be given probiotics lactobacillus reuteri 1.2 billion colony forming unit (CFU) sachets twice daily for swallowing with water for 12 weeks. Group C will be given lactobacillus sachets of same amount and participant will be asked to mix it with little amount of water and apply it on teeth with the toothbrush twice daily after brushing with standard tooth paste for 12 weeks. Patients will be recalled at the interval of 3, 6, 9 and 12 weeks for the recording of clinical periodontal parameters. After completion of trial plaque sample will be taken again from every participant and will be processed through qPCR to check bacterial count of porphyromonas gingivalis before and after treatment. Whereas comparison between clinical periodontal parameters will be made at the interval of 0, 3, 6, 9, 12 weeks. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03499184
Study type	Interventional
Source	Ziauddin Hospital
Contact
Status	Completed
Phase	N/A
Start date	November 1, 2017
Completion date	October 1, 2018

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT05231096` - Comparison of the Effect of Gingival Massage of Aloe-vera Gel and Sidr Honey on Chronic Periodontitis	N/A
Completed	`NCT03203746` - Gingival Crevicular Fluid Levels of Protein Carbonyl Following the Use of Lycopene in Chronic Periodontitis	Phase 1/Phase 2
Active, not recruiting	`NCT03354338` - Amoxicillin to Prevent Bacteria and Inflammatory Biomarkers After Intensive Periodontal Therapy	Phase 2
Completed	`NCT02516111` - Comparison of Autologous PRF, 1% Alendronate and 1.2% Atorvastatin Gel in Chronic Periodontitis Treatment	Phase 2/Phase 3
Completed	`NCT02174146` - Leptin and Visfatin in Diabetic Patients With Periodontitis Before and After Periodontal Therapy	N/A
Terminated	`NCT02568163` - Influence of Stress on Non Surgical Periodontal Treatment	N/A
Completed	`NCT02430519` - Benefits of Platelet Rich Fibrin In Mandibular Molar Furcation Defects	N/A
Completed	`NCT01233765` - Analysis of Neutrophil Response in Chronic Periodontitis	N/A
Completed	`NCT01438333` - Efficacy of INERSAN in Patients With Chronic Periodontitis as Adjunctive to Full Mouth Disinfection	N/A
Completed	`NCT02218515` - Treatment of Intrabony Periodontal Defects With Enamel Matrix Derivatives and Autogenous Bone Graft	Phase 4
Completed	`NCT02197260` - Antimicrobial Therapy as Adjunct to Periodontal Treatment: Effect of Timing	Phase 4
Not yet recruiting	`NCT03270280` - Comparison of Salivary Interleukin-1β and Matrix Metalloproteinase-8 Levels in Individuals With Chronic Periodontitis	Phase 2
Not yet recruiting	`NCT04026828` - Evaluation of Possible Genes in Periodontal Diseases by Genetic Methods
Completed	`NCT04697199` - The Adjunctive Effect of Probiotics to Non Surgical Treatment of Chronic Periodontitis	Phase 1
Completed	`NCT04643288` - Nanocrystalline Hydroxyapatite Bone Substitute for Treating Periodontal Intrabony Defects	N/A
Completed	`NCT03039244` - Evaluation of Antimicrobial Photodynamic Therapy as an Adjunct to Periodontal Treatment in Smokers	N/A
Completed	`NCT02898675` - Advantages of Autologous Platelet-Rich Fibrin Membrane on Growth Factor Levels and Periodontal Healing	N/A
Completed	`NCT02851823` - Combined Use of Er:YAG and Nd:YAG Laser	N/A
Completed	`NCT03874390` - Effects of Ozone Therapy on Clinical Parameters and Inflammatory Cytokines in Chronic Periodontitis Patients	N/A
Completed	`NCT02518152` - Platelet Rich Fibrin+1% Alendronate in Treatment of Chronic Periodontitis	Phase 2/Phase 3