Primary Sjögren Syndrome Clinical Trial
Official title:
Influenza, Pneumococcal and Diphtheria-tetanus-poliomyelitis Vaccine Coverage in Patients With Primary Sjögren's Syndrome: a Cross-sectional Study
Evaluation of vaccination coverage for influenza, pneumococcus and DTP in patients with pSS and investigated the reasons for non-vaccination.
A cross-sectional study was performed in pSS patients from two different French tertiary
referral centers for autoimmune diseases (Paris-Bicêtre and Montpellier). From January 2016
to November 2017, questionnaires were randomly delivered to patients with pSS according to
European-American Diagnostic Criteria (2002). Before completing the questionnaire, patients
gave their consent to participate. This questionnaire was adapted from questionnaires used by
the French national agency "Institut de Veille Sanitaire" to study vaccination coverage and
were completed with the assistance of one fellow (HL) to limit missing data.
Data collected in the questionnaire included previous vaccinations, reasons for
non-vaccination, sources of vaccine proposition, and sociodemographic data including
education level (Bachelor degree, and post-Bachelor degree education) and presence of young
child(ren) (inferior 10 years old) at home. The following data was collected from the medical
file: European-American Diagnostic Criteria (2002) for pSS, the most recent EULAR Sjögren's
syndrome disease activity index (ESSDAI), comorbidities (chronic lung diseases, diabetes,
chronic kidney diseases, chronic liver diseases, chronic heart diseases, cardiovascular
comorbidities [coronary or cerebral ischemia] and severe neurological or muscle diseases),
history of severe A cross-sectional study was performed in pSS patients from two different
French tertiary referral centers for autoimmune diseases (Paris-Bicêtre and Montpellier).
From January 2016 to November 2017, questionnaires were randomly delivered to patients with
pSS according to European-American Diagnostic Criteria (2002). Before completing the
questionnaire, patients gave their consent to participate. This questionnaire was adapted
from questionnaires used by the French national agency "Institut de Veille Sanitaire" to
study vaccination coverage and were completed with the assistance of one fellow (HL) to limit
missing data. Data collected in the questionnaire included previous vaccinations, reasons for
non-vaccination, sources of vaccine proposition, and sociodemographic data including
education level (Bachelor degree, and post-Bachelor degree education) and presence of young
child(ren) (inferior 10 years old) at home. The following data was collected from the medical
file: European-American Diagnostic Criteria (2002) for pSS, the most recent EULAR Sjögren's
syndrome disease activity index (ESSDAI), comorbidities (chronic lung diseases, diabetes,
chronic kidney diseases, chronic liver diseases, chronic heart diseases, cardiovascular
comorbidities [coronary or cerebral ischemia] and severe neurological or muscle diseases),
history of severe infection (requiring intravenous antibiotics or hospital admission),
current smoking status, treatments used for pSS including hydroxychloroquine,
immunosuppressive drugs (methotrexate, leflunomide, ciclosporine, azathioprine, mycophenolate
mofetil) and biological disease-modifying anti-rheumatic drugs (bDMARDs).
For descriptive statistical analysis, mean more or less SD were used for continuous variables
and frequencies (percentage) for categorical variables. To evaluate factors associated with
up-to-date vaccination, the investigators compared categorical variables between patients
with updated and non-updated influenza, pneumococcal or DTP vaccines by using the Fisher
exact test or chi-square test as appropriate. Continuous variables (age, ESSDAI) were
compared by Student t test. A binary logistic regression model was used for multivariate
analysis to estimate the odds ratio (OR) of being vaccinated with the 95% confidence interval
(CI). p< 0.05 was considered statistically significant. All statistical analyses were
performed with IBM SPSS 15 software.
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