68Ga-P16-093 PET/CT Imaging in the Salivary Gland

Status Not yet recruiting

Clinical Trial Summary

Prostate specific membrane antigen (PSMA) is a type II transmembrane protein and acts as a glutamate carboxypeptidase enzyme. It is first described in prostate cancer cell lines and later identified in various tissues, include salivary gland. This pilot study was designed to evaluate the diagnostic performance of 68Ga-P16-093 in primary sjogren's syndrome patients.

Clinical Trial Description

Primary sjogren's syndrome (pSS) is a systemic autoimmune disease mainly presented hyperglobulinemia and exocrine gland involvement,and lack of diagnostic gold standard.Prostate-specific membrane antigen (PSMA), as known as folate hydrolase I or glutamate carboxypeptidase II, is overexpressed on the cells of prostatic adenocarcinoma. However, PSMA is also expressed by various solid organs , such as salivary gland,which is often observed damage in primary Sjogren's syndrome patients.Therefore, PSMA may be an ideal target for evaluating salivary gland injury. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06049368
Study type	Interventional
Source	Peking Union Medical College Hospital
Contact	Zhaohui Zhu, MD
Phone	86-13611093752
Email	13611093752@163.com
Status	Not yet recruiting
Phase	Phase 1/Phase 2
Start date	October 1, 2023
Completion date	March 31, 2024

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