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Tear Analysis in the Diagnosis of Multiple Sclerosis — LARMES  

Primary Progressive Multiple Sclerosis Clinical Trial

Official title:
Tear Analysis in the Diagnosis of Primary Progressive Forms of Multiple Sclerosis

Clinical Trial Summary

In the primary progressive multiple sclerosis, the detection of oligoclonal bands in cerebrospinal fluid is critical for the diagnosis. However, lumbar puncture for cerebrospinal fluid collection is considered relatively invasive. Our hypothesis is that oligoclonal bands detection in tears is possible and useful for the diagnosis of multiple sclerosis.

Clinical Trial Description

The objective of the present study is to assess concordance between oligoclonal bands detection in tears and in cerebrospinal fluid. We will include patients with primary progressive multiple sclerosis and we will compare results of oligoclonal bands detection by isoelectric focusing in cerebrospinal fluid and tears. Tears will be collected using a Schirmer strip. This would circumvent the practice of invasive lumbar punctures currently used in multiple sclerosis diagnosis. ;

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02016222
Study type Interventional
Source Lille Catholic University
Contact
Status Completed
Phase N/A
Start date April 2011
Completion date March 2016
View Details
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