Primary Open Angle Glaucoma Clinical Trial
— CATALYSTOfficial title:
Cataract Surgery in Conjunction With Ab-interno Canaloplasty Compared to Cataract Surgery Only in Patients With Mild to Moderate Primary Open-Angle Glaucoma
A prospective, multicenter, randomized, single-masked, post-market clinical trial comparing cataract surgery in conjunction with ab-interno canaloplasty utilizing the iTrack Advance canaloplasty device (Nova Eye, Inc.) to cataract surgery only in patients with mild to moderate, primary open angle glaucoma. Subjects will be followed for 12 months.
Status | Recruiting |
Enrollment | 78 |
Est. completion date | October 2025 |
Est. primary completion date | September 2025 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 55 Years and older |
Eligibility | Inclusion Criteria: - Mild to moderate, primary open angle glaucoma - Characteristics consistent with mild to moderate glaucoma - Use of 1 - 4 ocular hypotensive medications at the Screening exam and meets the IOP (intraocular pressure) criteria - Visually significant cataract Exclusion Criteria: Any of the following prior treatments for glaucoma (study eye): - Laser Trabeculoplasty - Endocyclophotocoagulation (ECP) or Micropulse laser - iStent or iStent Inject - Hydrus Microstent - Trabeculectomy or other bleb forming procedure including Xen, Express, and glaucoma drainage device/valve. - Prior canaloplasty (ab-interno and ab-externo) - Suprachoroidal stent (e.g., Cypass, iStent Supra, XEN) - Concurrent IOP-lowering procedure other than use of the iTrackTM Advance canaloplasty device at the time of surgery (e.g., ECP, CPC, etc.) - Previous treatment with iTrack (Note: permitted if fellow eye only was treated) - Acute angle closure, traumatic, congenital, malignant, uveitic or neovascular glaucoma, pigmentary glaucoma or pseudo exfoliative glaucoma. |
Country | Name | City | State |
---|---|---|---|
Germany | University of Bonn Eye Clinic | Bonn | |
Germany | St. Johannes Hospital | Dortmund | |
Germany | Augencentrum Köln Ophthalmology | Köln |
Lead Sponsor | Collaborator |
---|---|
Nova Eye, Inc. | Nova Eye Medical GmbH |
Germany,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Reduction in mean Intraocular Pressure (IOP) at 12 months compared to baseline | IOP will be measured at each study visit using Goldmann applanation tonometry | 12 months | |
Secondary | To evaluate the reduction in number of glaucoma medications at 12 months compared to baseline | 12 months |
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