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Clinical Trial Summary

The purpose of this study is to perform exploratory analyses to evaluate rates of functional and structural change in glaucoma, to identify predictors of rapid progression in patients with glaucoma and to identify possible genetic factors and biomarkers associated with the disease.


Clinical Trial Description

PRIMARY OBJECTIVES To identify and combine a set of predictors (i.e. by statistical modeling, machine learning classifiers or neural networks) to predict progression in glaucoma patients To determine how to most sensitively and specifically determine progression for a trial of a potential neuroprotective agent. SECONDARY OBJECTIVES To evaluate genetic and other potential biomarkers associated with progression in glaucoma. To evaluate tests currently used on glaucoma patients to better predict which ones are most sensitive to detect disease progression and measure rates of change. To assess progression by structural and functional tests: - Optic disc stereophotographs - Cirrus OCT - RTVue OCT - Standard Automated Perimetry (SAP) - Frequency Doubling Technology Matrix ;


Study Design


Related Conditions & MeSH terms


NCT number NCT01442896
Study type Observational
Source University of California, San Diego
Contact
Status Completed
Phase
Start date September 1, 2011
Completion date December 18, 2015

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