Clinical Trials Logo
  1. Home
  2. Primary Hypertension
  3. NCT00865501
  4. Details
NCT00865501 Clinical Trial

Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Primary Hypertension Clinical Trial

Official title:
Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT00865501
Other study ID # KFO-TP5-I
Secondary ID
Status Completed
Phase Phase 3
First received March 18, 2009
Last updated July 6, 2012
Start date March 2008
Est. completion date December 2009

Study information
Verified date July 2012
Source University of Erlangen-Nürnberg Medical School
Contact n/a
Is FDA regulated No
Health authority Germany: Federal Institute for Drugs and Medical Devices
Study type Interventional

Clinical Trial Summary

The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

Recruitment information / eligibility
Status Completed
Enrollment 50
Est. completion date December 2009
Est. primary completion date December 2009
Accepts healthy volunteers No
Gender Male
Age group 18 Years to 40 Years
Eligibility Inclusion Criteria:

- Clinical diagnosis hypertension (BP higher than 139/89)

Exclusion Criteria:

- Antihypertensive pretreatment

- Contraindications against spironolactone

- Being unable to understand or comply with study procedures

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Intervention

Drug:
• spironolactone
25mg per oral once daily
• placebo
placebo

Locations
Country Name City State
Germany University Erlangen-Nürnberg, Nephrology and Hypertension Erlangen

Sponsors (1)
Lead Sponsor Collaborator
University of Erlangen-Nürnberg Medical School

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary left ventricular mass 8 weeks No
See also
  Status Clinical Trial Phase
Completed NCT00573742 - Efficacy Observational Study of Candesartan Cilexetil on Hypertensive Patients N/A
Recruiting NCT06208072 - The Predictive Role of Urinary Proteomics in Blood Pressure Response of Obese Hypertensive Treated With Irbesartan or Eplerenone. N/A
Recruiting NCT06049862 - The Effectiveness of "MaRiTensi" in Increasing Self-Care and Blood Pressure Control: Randomized Controlled Trial N/A
Completed NCT00819104 - A Study to Compare the Efficacy, Safety and Tolerability of Selomax With Its Individual Components Phase 4
Not yet recruiting NCT06091176 - Assessment of Efficacy and Safety of Amicomed®, for the Management of Essential Hypertension N/A
Recruiting NCT01742702 - HaemoDYNAMICs in Primary and Secondary Hypertension
Recruiting NCT02817204 - Effect of Aerobic EXercise on MiCroVAscular RarefacTION in Chinese Mild HyperteNsive Patients（EXCAVATION-CHN1） Phase 3
Completed NCT00794885 - China Stroke Primary Prevention Trial Phase 4
Active, not recruiting NCT04381520 - Heat-sensitive Moxibustion Self-administration in Patients in the Community With Primary Hypertension: Protocol for a Multi-center, Pragmatic, Non-randomized Trial N/A
Active, not recruiting NCT04788563 - A Randomized Patient Preference Trial on Heat-sensitive Moxibustion for Primary Hypertension in Community N/A
Completed NCT02184858 - Dose Titration of Lisinopril in Children Aged 1 to 18 Years With Primary or Secondary Hypertension Phase 4
Completed NCT03105687 - Effectiveness of SMS Reminders of Blood Pressure-lowering Drugs Intake N/A
Completed NCT01392534 - Effects of Telmisartan/Hydrochlorothiazide Treatment in Hypertensive Patients Under Real-life Setting N/A
Active, not recruiting NCT03015311 - Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients N/A
Enrolling by invitation NCT03470974 - The Effect of Self-Titration and Predictors for Blood Pressure Control in Patients With Hypertension N/A
Active, not recruiting NCT01844570 - Levamlodipine Maleate or Amlodipine Besylate for Treatment of Hypertension: A Comparative Effectiveness Research N/A
Completed NCT01241487 - A National Multicentre Study to Assess the Efficacy of the Fixed Combination of Valsartan and Amlodipine in Hypertensive Patients Not Controlled by Monotherapy Phase 4
Completed NCT00882947 - Post-Marketing Surveillance of Ventavis® in Chinese Patients With Primary Pulmonary Hypertension (PPH) Phase 4
Active, not recruiting NCT03310684 - Pediatric Primary Hypertension and the Renin-Angiotensin System (PHRAS)
Not yet recruiting NCT02901704 - Renal Denervation by Iberis MultiElectrode Renal Denervation System in Patients With Primary Hypertension Phase 3