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Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Primary Hypertension Clinical Trial

Official title:
Importance of Aldosterone in the Pathogenesis of Hypertensive Heart Disease

Clinical Trial Summary

The Renin-Angiotensin-Aldosterone-system is important in the development of cardiovascular organ damage caused by arterial hypertension. This study aims at evaluating the importance of aldosterone with regard to hypertension induced damage to the heart. In order to do this the investigators will perform a comparative cross-sectional study in hypertensives and normotensives. In addition as interventional part the hypertensives will be treated with a mineralocorticoid-receptor blocker (spironolactone).

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00865501
Study type Interventional
Source University of Erlangen-Nürnberg Medical School
Contact
Status Completed
Phase Phase 3
Start date March 2008
Completion date December 2009
View Details
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