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CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

Primary Graft Dysfunction Clinical Trial

Official title:
CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation

Clinical Trial Summary

Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate multiple prognostic factors that influence long term survival after lung transplantation with a specific interest in PGD, acute rejection and the development of CLAD.

Clinical Trial Description

At specific time points (according to protocol) exhaled breath, blood specimens, bronchoalveolar lavage and biopsies will be collected. These will be analyzed in an attempt to identify possible biomarkers that will predict the development of PGD and/or CLAD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04558333
Study type Observational
Source University Hospital, Antwerp
Contact Johanna M Kwakkel-van Erp, MD, PhD
Phone 38215469
Email johanna.Kwakkel-vanErp@uza.be
Status Recruiting
Phase
Start date October 28, 2019
Completion date October 2039
View Details
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