Clinical Trials Logo

Clinical Trial Summary

Lung transplantation is the ultimate treatment for end stage lung diseases. Survival after lung transplantation is limited mainly due to the development of chronic allograft dysfunction (CLAD). Both acute cellular rejection and primary grade dysfunction (PGD) have been associated with the development of CLAD. In this study we will investigate multiple prognostic factors that influence long term survival after lung transplantation with a specific interest in PGD, acute rejection and the development of CLAD.


Clinical Trial Description

At specific time points (according to protocol) exhaled breath, blood specimens, bronchoalveolar lavage and biopsies will be collected. These will be analyzed in an attempt to identify possible biomarkers that will predict the development of PGD and/or CLAD. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04558333
Study type Observational
Source University Hospital, Antwerp
Contact
Status Terminated
Phase
Start date October 28, 2019
Completion date February 28, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT05375149 - Exhaled Breath Particles in Lung Transplantation
Recruiting NCT01605214 - Measurement of Extravascular Lung Water to Detect and Predict Primary Graft Dysfunction Following Lung Transplant N/A
Terminated NCT01715883 - Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction Phase 2
Recruiting NCT01151826 - Quantifying Physical and Biochemical Factors That Contribute to Primary Graft Dysfunction After Lung Transplantation N/A
Recruiting NCT05691205 - Identifying Optimal PEEP After Lung Transplantation N/A
Completed NCT02032069 - Pneumoproteins Expression in the Organ Donor N/A
Completed NCT01967953 - Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation Phase 1
Recruiting NCT00506532 - The Use of Surfactant in Lung Transplantation: A Randomized Control Pilot Study Phase 2/Phase 3
Completed NCT06159933 - Primary Graft Dysfunction, Pronation, Bilateral Lung Transplants N/A
Recruiting NCT03156894 - Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience N/A
Recruiting NCT00457847 - Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation
Recruiting NCT00552357 - Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation
Withdrawn NCT04505878 - Perioperative Vitamin C Lung Transplant Phase 2