Clinical Trials Logo
  1. Home
  2. Primary Graft Dysfunction
  3. NCT01151826

Quantifying Physical and Biochemical Factors That Contribute to Primary Graft Dysfunction After Lung Transplantation

Primary Graft Dysfunction Clinical Trial

Official title:
Measurement of Physical and Biochemical Markers of Reperfusion Edema During Primary Graft Dysfunction Following Lung Transplantation. Assessment of Their Diagnosis and Prognosis Values

Clinical Trial Summary

Primary graft dysfunction (PGD or lung reperfusion edema) complicates 10 to 20% of lung transplantations and leads to severe early and late postoperative complications. Its pathophysiology remains unclear but may involve graft ischemia-reperfusion, increased vascular permeability, pneumocyte dysfunction and finally alveolar flooding that impair gas exchange and blood oxygenation.Its substrate, namely extravascular lung water (EVLW), can now be clinically measured with minimally invasive Intensive Care Unit monitors (PiCCO2®, Pulsion Medical Systems) that also provides a physical estimate of pulmonary vascular permeability (PVPI). Similarly, biochemical correlates of vascular permeability (ICAM-1) and pneumocyte dysfunction (RAGE) can now be measured in plasma samples. Our study aims at quantifying physical and biochemical markers of PGD and assess their diagnosis and prognosis values.

Clinical Trial Description

n/a

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01151826
Study type Observational
Source University Hospital, Strasbourg, France
Contact Julien Pottecher, MD
Phone 33 3 69 55 04 44
Email julien.pottecher@chru-strasbourg.fr
Status Recruiting
Phase N/A
Start date July 2010
Completion date August 2012
View Details
See also
  Status Clinical Trial Phase
Recruiting NCT05375149 - Exhaled Breath Particles in Lung Transplantation
Recruiting NCT04558333 - CLAD: Finding Biomarkers to Predict Rejection and/ or Outcome After Lung Transplantation
Recruiting NCT01605214 - Measurement of Extravascular Lung Water to Detect and Predict Primary Graft Dysfunction Following Lung Transplant N/A
Terminated NCT01715883 - Sodium Nitrite in Lung Transplant Patients to Minimize the Risk of Pulmonary Graft Dysfunction Phase 2
Recruiting NCT05691205 - Identifying Optimal PEEP After Lung Transplantation N/A
Completed NCT02032069 - Pneumoproteins Expression in the Organ Donor N/A
Completed NCT01967953 - Ex-Vivo Lung Perfusion to Increase the Number of Organs for Transplantation Phase 1
Recruiting NCT00506532 - The Use of Surfactant in Lung Transplantation: A Randomized Control Pilot Study Phase 2/Phase 3
Completed NCT06159933 - Primary Graft Dysfunction, Pronation, Bilateral Lung Transplants N/A
Recruiting NCT03156894 - Heart Transplant and Primary Transplant Dysfunction: a Retrospective Analysis of the Strasbourg Experience N/A
Recruiting NCT00457847 - Identifying Genetic Characteristics That Increase Risk of Primary Graft Dysfunction Following Lung Transplantation
Recruiting NCT00552357 - Risk Factors That Increase the Chance of Developing Primary Graft Dysfunction After Lung Transplantation
Withdrawn NCT04505878 - Perioperative Vitamin C Lung Transplant Phase 2