Prospective Genetic Study in Patients With Ovarian Insufficiency

Status Recruiting

Clinical Trial Summary

genetic screening and etiological analysis was conducted on patients with ovarian insufficiency and decline in ovarian reserve. All patients were enrolled in the IVF-treated and non-IVF-treated groups, followed up for long-term treatment outcomes and genomic screening.

Clinical Trial Description

The cause of ovarian insufficiency and decline in ovarian reserve are not clear, but most researchers think the probable causes are mainly three aspects: chromosomal abnormalities, genetic factors and autoimmune diseases，But the majority of patients with normal chromosome karyotype analysis. The screening of pathogenic genes in patients with normal karyotype is the focus of current premature ovarian insufficiency(POI) and decline in ovarian reserve(DOR) etiology, to further explain the pathogenesis of patients, improve the diagnosis of those diseases and Clinical treatment. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03474120
Study type	Observational
Source	The First Affiliated Hospital of Anhui Medical University
Contact	Yiran Zhou, bachelor
Phone	+86 13605690313
Email	zhouyiran0309@163.com
Status	Recruiting
Phase
Start date	April 20, 2018
Completion date	December 24, 2023

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