Premature Ovarian Failure Clinical Trial
Official title:
"It is a Real" The First Baby Of Autologous Stem Cell Therapy in Premature Ovarian Failure
The purpose of this work is to evaluate the therapeutic potential of Autologous Mesenchymal sc (MSC) therapy in women suffering from POF.
Stem cells (sc) are the foundation cells for every organ, tissue and cell in the body. They are self sustaining and can replicate themselves for long periods of time. They have the remarkable potential to develop in many different cell types in the body. Premature ovarian failure (POF) is the loss of ovarian function in women less than 40 years. It is associated with sex steroid deficiency, amenorrhea, infertility, and elevated serum gonadotropins. This work aimed to evaluate the therapeutic potential of Autologous Mesenchymal sc (MSC) transplantation in women suffering from POF. Out of 112 high risk patients for POF, 10 cases were diagnosed as POF. The ten POF patients were scheduled for MSC transplantation at Al- Azhar University Hospitals. MSC preparation from the bone marrow of the iliac crest was laparoscopically injected in the ovaries. Endometrial fractional biopsy is histopathologically (HP) and Immunohistochemically (IH) stained and evaluated according to Edessy stem cells score (ESS) (1). ;
Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Unknown status |
NCT01853501 -
Effects of ADSC Therapy in Women With POF
|
Phase 4 | |
| Completed |
NCT00417066 -
Flexible GnRH Antagonist vs Flare up GnRH Agonist Protocol in Poor Responders
|
Phase 4 | |
| Active, not recruiting |
NCT04675970 -
Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy
|
||
| Recruiting |
NCT03480412 -
Second Step Protocol in Poor Ovarian Responder (POR)
|
||
| Completed |
NCT02644447 -
Transplantation of HUC-MSCs With Injectable Collagen Scaffold for POF
|
Phase 1/Phase 2 | |
| Completed |
NCT03840824 -
Blood Spot Self-administered Test and Assay
|
||
| Recruiting |
NCT00119925 -
'SPRING'-Study: "Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists"
|
N/A | |
| Recruiting |
NCT06117982 -
The Impact of Granulocyte Colony Stimulating Factor on Premature Ovarian Insufficiency
|
Phase 2 | |
| Suspended |
NCT03816852 -
The Safety and Efficiency Study of Mesenchymal Stem Cell (19#iSCLife®-POI) in Premature Ovarian Insufficiency
|
Phase 2 | |
| Not yet recruiting |
NCT04390308 -
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
|
||
| Completed |
NCT02783937 -
Filgrastim for Premature Ovarian Insufficiency
|
Phase 4 | |
| Completed |
NCT00295087 -
X-Chromosome Inactivation Status and Premature Ovarian Failure
|
N/A | |
| Completed |
NCT00429494 -
GnRH Analogue for Ovarian Function Preservation in Hematopoietic Stem Cell Transplantation Patients
|
Phase 2 | |
| Not yet recruiting |
NCT05522634 -
A Clinical Study of Chinese Herbal Compound TJAOA101 in the Treatment of Premature Ovarian Insufficiency
|
Early Phase 1 | |
| Recruiting |
NCT05838157 -
The Effect of HPV Vaccine on Menstrual Cycle in Women of Reproductive Age
|
||
| Withdrawn |
NCT01129947 -
The Use of DHEA in Women With Premature Ovarian Failure
|
Phase 0 | |
| Completed |
NCT00001275 -
Ovarian Follicle Function in Patients With Primary Ovarian Failure
|
N/A | |
| Not yet recruiting |
NCT04306185 -
Ovarian Fragmentation Study (Crespo Medical Team)
|
N/A | |
| Recruiting |
NCT02062931 -
Autologous Mesenchymal Stem Cells Transplantation In Women With Premature Ovarian Failure
|
Phase 1/Phase 2 | |
| Completed |
NCT02151890 -
Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure
|
Phase 1/Phase 2 |