Premature Ovarian Failure Clinical Trial
Official title:
Pregnancy After Stem Cell Transplantation in Premature Ovarian Failure (POF)
Out of 112 high risk patients for Premature Ovarian Failure (POF), diagnosis was established
in 10 cases.
ESS cut off point for menstruation and pregnancy was 6.
Out of 112 high risk patients for POF, diagnosis was established in 10 cases. Endometrial
fractional biopsy was taken, stained with H&E stain and by immubohistchemical (IH) staining
by stem cell marker OCT4. IH expression of stem cell marker OCT4 was evaluated before and
after transplantation according to Edessy Stem Cell Score (ESS).
After laparoscopic injection of stem cell sample in the ovaries, participants were followed
up monthly for a period of one year by hormonal (FSH, LH and E2), clinical (resuming
menstruation), US (folliculometry), histopathological (HP), and IH expression of stem cell
(stem cell positivity and scoring according to ESS).
These cases were of ESS 5 and 6.
;
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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