Premature Ovarian Failure Clinical Trial
Official title:
Effects of Adipose Derived Stem Cell Therapy in Women With Premature Ovarian Failure
Verified date | November 2013 |
Source | Nanjing University |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The purpose of this study is to determine whether Adipose Derived Stem Cells are effective in the treatment of Premature Ovarian Failure (POF). Stem cell transplantation has been reported to rescue ovarian function in a pre-clinical mouse model of chemotherapy-induced POF; however, maintaining the survival of transplanted cells in human ovarian tissues to enable the POF patients regain ovary function over the long-term and achieving a successful pregnancy remain a troublesome issue. In this study the investigators are aiming to determine whether the CD29+/CD44+ human Adipose Derived Stem Cells could later enable ovaries produce mature oocytes.
Status | Unknown status |
Enrollment | 4 |
Est. completion date | September 2014 |
Est. primary completion date | September 2014 |
Accepts healthy volunteers | No |
Gender | Female |
Age group | 20 Years to 39 Years |
Eligibility |
Inclusion Criteria: - Clinical diagnosis of Premature Ovarian Failure - Patients show no response to drug treatment - Willing to receive follow up - Willing to conceive a baby - Age between 20 to 39 Exclusion Criteria: - Patients with few abdominal fat - Patients with chromosome abnormalities - Patients with congenital ovarian malformations - Patients with severe endometriosis - Patients with thyroid dysfunction - Patients with pregnancy contraindications - Patients with hormone replacement therapy contraindications - Patients with liposuction contraindications - Past history of ovarian tumors or after radiotherapy - Can not take the follow-up, or want to take other treatment during the follow-up period - Patients with immune system diseases |
Country | Name | City | State |
---|---|---|---|
China | The Affiliated Drum Tower Hospital of Nanjing University | Nanjing | Jiangsu |
Lead Sponsor | Collaborator |
---|---|
Nanjing University |
China,
Cho WK, Lee JW, Chung NG, Jung MH, Cho B, Suh BK, Kim HK. Primary ovarian dysfunction after hematopoietic stem cell transplantation during childhood: busulfan-based conditioning is a major concern. J Pediatr Endocrinol Metab. 2011;24(11-12):1031-5. — View Citation
Feng W, Cui Y, Zhan H, Shi M, Cui W, Guo K, Li Q, Song C, Zhang Y, Mori T, Gershwin ME, Abraham NG, Ikehara S. Prevention of premature ovarian failure and osteoporosis induced by irradiation using allogeneic ovarian/bone marrow transplantation. Transplantation. 2010 Feb 27;89(4):395-401. doi: 10.1097/TP.0b013e3181ca86bb. — View Citation
Lin G, Wang G, Banie L, Ning H, Shindel AW, Fandel TM, Lue TF, Lin CS. Treatment of stress urinary incontinence with adipose tissue-derived stem cells. Cytotherapy. 2010;12(1):88-95. doi: 10.3109/14653240903350265. — View Citation
Silber SJ. Ovary cryopreservation and transplantation for fertility preservation. Mol Hum Reprod. 2012 Feb;18(2):59-67. doi: 10.1093/molehr/gar082. Epub 2011 Dec 28. Review. — View Citation
Takehara Y, Yabuuchi A, Ezoe K, Kuroda T, Yamadera R, Sano C, Murata N, Aida T, Nakama K, Aono F, Aoyama N, Kato K, Kato O. The restorative effects of adipose-derived mesenchymal stem cells on damaged ovarian function. Lab Invest. 2013 Feb;93(2):181-93. d — View Citation
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---|---|---|---|---|
Primary | Antral follicle diameter | Antral follicle diameter were record using transvaginal ultrasound scan. | within the first 30 weeks (plus or minus 10 weeks) after surgery |
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