Pregnancy Clinical Trial
Official title:
Correlates of Maternal Characteristics in CMV Infection in Pregnancy With Maternal-fetal Transmission.
Analysis of several characteristics of blood from pregnant women with CMV infection according to maternal-fetal transmission. These include CMV viral load, cytokine profile in response to in-vitro stimulation with CMV peptides, meticulous analysis of anti CMV antibodies, maternal DNA polymorphism and microarray of gene expression.
Maternal Cytomegalovirus infection in pregnancy may cause significant morbidity in the fetus.
Intrauterine CMV transmission occurs mainly during primary maternal infections, with a
maternal-fetal transmission rate of about 40%. The mechanisms dictating CMV intrauterine
transmission are unknown, and transmission is currently thought to be dependent on multiple
factors, including the maternal and fetal immune system.
To investigate the mechanism of transmission approaching laboratory prediction of
transmission, the investigators collect blood from pregnant women with primary CMV infection,
and analyze several characteristics. These include CMV viral load, cytokine profile in
response to in-vitro stimulation with CMV peptides, meticulous analysis of anti CMV
antibodies, maternal DNA polymorphism and microarray of gene expression.
These results will be analysed according to transmission as indicated by a positive culture /
Polymerase chain transcription of amniotic fluid or newborns urine / saliva.
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