Pregnancy Clinical Trial
Official title:
The Feasibility of Screening for Smith-Lemli-Opitz Syndrome
Smith-Lemli-Opitz Syndrome (SLOS) is a genetic condition that causes mental retardation and other birth defects. This study will evaluate a new prenatal screening test for SLOS.
Status | Completed |
Enrollment | 1800 |
Est. completion date | July 2005 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Female |
Age group | N/A and older |
Eligibility |
Inclusion Criteria - Pregnant, second trimester - Singleton pregnancy - Positive second trimester maternal serum screen for Smith-Lemli-Opitz Syndrome (using the Foundation for Blood Research screening algorithm ) Exclusion criteria: - Gestational age at time of serum collection outside the range accepted for Down Syndrome screening - Not pregnant - Twin/multiple pregnancy - Sample/clerical/assay error - Physician not participating in study |
Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
Country | Name | City | State |
---|---|---|---|
United States | Foundation for Blood Research | Scarborough | Maine |
Lead Sponsor | Collaborator |
---|---|
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) |
United States,
Palomaki GE, Bradley LA, Knight GJ, Craig WY, Haddow JE. Assigning risk for Smith-Lemli-Opitz syndrome as part of 2nd trimester screening for Down's syndrome. J Med Screen. 2002;9(1):43-4. — View Citation
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