Outcome
Type |
Measure |
Description |
Time frame |
Safety issue |
Primary |
Endothelial Function |
The investigators will assess endothelial function using flow mediated dilation |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Cardiovascular Function - arterial stiffness with pulse wave velocity |
The investigators will measure arterial stiffness using pulse wave velocity of the carotid and femoral arteries |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Cardiovascular Function - arterial stiffness with beat-by-beat blood pressure |
The investigators will measure arterial stiffness using beat-by-beat blood pressure from the finger. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Cardiovascular Function - ambulatory blood pressure |
Blood pressure will be collected every 30 minutes during a 24-hour period using an ambulatory blood pressure monitor. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Cardiovascular Function - resting blood pressure |
Beat-by-beat blood pressure will be collected at rest. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Cardiovascular Function - heart rate |
Heart rate will be assessed by 3-lead ECG collected during sleep and at rest. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Cardiovascular Function - arrythmias |
Presence of arrythmias will be assessed by 3-lead ECG collected during sleep and at rest. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Maternal outcome - dietary intake |
Participants will complete two 3-day food logs. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Fasted blood sample - blood viscosity |
Fasted blood samples will be analyzed using a viscometer. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Fasted blood sample - presence of inflammatory markers |
Fasted blood samples will be analyzed for C-reactive protein. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Fasted blood sample - sex hormone levels |
Fasted blood samples will be analyzed for sex hormone levels (estrogen, progesterone, testosterone). |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Fasted blood sample - metabolic |
Fasted blood samples will be analyzed for glucose and insulin concentration. |
20-24 weeks and 28-36 weeks gestation |
|
Secondary |
Maternal outcomes - delivery |
Participants will provide the investigators with information regarding delivery and pregnancy complications (gestational diabetes, pregnancy induced hypertension, preeclampsia). |
2 months postpartum |
|
Secondary |
Fetal outcomes at delivery - infant sex |
Participants will provide the investigators with information regarding infant sex. |
2 months postpartum |
|
Secondary |
Fetal outcomes at delivery - birth weight |
Participants will provide the investigators with information regarding infant birth weight. |
2 months postpartum |
|
Secondary |
Fetal outcomes at delivery - birth length |
Participants will provide the investigators with information regarding birth length. |
2 months postpartum |
|
Secondary |
Fetal outcomes at delivery - gestational age |
Participants will provide the investigators with information regarding gestational age at delivery. |
2 months postpartum |
|
Secondary |
Fetal outcomes at delivery - birth mode |
Participants will provide the investigators with information regarding birth mode. |
2 months postpartum |
|
Secondary |
Fetal outcomes at delivery - apgar score |
Participants will provide the investigators with information regarding infant apgar score at delivery. |
2 months postpartum |
|
Secondary |
Fetal outcomes at delivery - time spent in NICU |
Participants will provide the investigators with information regarding infant time spent in neonatal intensive care unit (NICU). |
2 months postpartum |
|
Secondary |
Maternal outcome - amount of activity |
Participants will wear two accelerometers to measure the amount of physical activity performed. |
20-24 weeks and 28-36 weeks |
|
Secondary |
Maternal outcome - Mood - State-Trait Anxiety Inventory |
Participants will complete the State-Trait Anxiety Inventory to measure mood. |
20-24 weeks and 28-36 weeks |
|
Secondary |
Maternal outcome - Mood - Edinburgh Postnatal Depression Scale |
Participants will complete the Edinburgh Postnatal Depression Scale to measure mood. |
20-24 weeks and 28-36 weeks |
|