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Clinical Trial Summary

The goal of this clinical trial is to compare post-operative uterine scar thickness in people who have had the uterus closed during cesarean sections by one of three different methods. The main questions it aims to answer are: - Residual myometrial thickness at the scar site assessed by MRI performed 4 months after the procedure - Myometrial niche formation assessed by MRI performed 4 months after the procedure - Scar healing ratio (HR) difference as defined by HR= residual myometrial thickness/total myometrial thickness - Post-operative change in hemoglobin - Time required for hysterotomy closure - The number of extra sutures required to achieve surgeon-acceptable hemostasis Participants undergoing scheduled cesarean sections will be randomized to one of three different uterine closure methods. The methods are: 1. Single layer closure using the following technique: Closure of the myometrium and serosa with one barbed suture using a running unlocked technique. The endometrium should be excluded. 2. Double layer closure using the following technique: Closure of the full thickness of the myometrium with one smooth suture using a running locked technique. The endometrium should be excluded. Followed by imbrication of the second layer with one smooth suture using a running unlocked technique. 3. Triple layer closure of Endometrium, Myometrium and Serosa (EMS) using one of the the following two techniques: Closure of the endometrium and 2-4 mm of internal myometrium with one barbed suture using a running unlocked technique followed by closure of the remaining myometrium and serosa with one barbed suture using a running unlocked technique. Or, Closure of the endometrium and 2-4 mm of internal myometrium with one barbed suture on using a running unlocked technique followed by closure of the remaining myometrium with one barbed suture a running unlocked technique followed by closure of the serosa with one barbed suture using a running unlocked technique. Four months after the surgery, participants will have a MRI of the pelvis to assess the scar on the uterus.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT05750394
Study type Interventional
Source Brigham and Women's Hospital
Contact James A. Greenberg, MD
Phone 7819101968
Email jagreenberg@bwh.harvard.edu
Status Not yet recruiting
Phase N/A
Start date July 2023
Completion date July 2025

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