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Natural Versus Programmed Frozen Embryo Transfer (NatPro) — NatPro  

Pregnancy Related Clinical Trial

Official title:
Multi-center, Parallel-group, Randomized Controlled Trial of Modified Natural Versus Programmed Cycles for Frozen Embryo Transfers and Their Association With Preeclampsia and Live Births

Clinical Trial Summary

NatPro is a two-arm, parallel-group, multi-center, randomized trial in which women undergoing frozen embryo transfer (FET) will be randomized to receive either a modified natural cycle (corpus luteum present) or a programmed cycle (corpus luteum absent).

Clinical Trial Description

NatPro is a two-arm, parallel-group, multi-center, randomized trial in which women undergoing FET will be randomized to receive either a modified natural cycle (corpus luteum present) or a programmed cycle (corpus luteum absent). The study will implement a stratified randomization design to balance the use of pre-implantation genetic testing (PGT) across the two treatment arms. Each participant will have up to 3 FET cycles until live birth occurs, or the participant has no embryos available for transfer. Primary endpoints will be the proportion of women experiencing preeclampsia comparing modified natural to programmed FET among women with viable pregnancy (defined as pregnancy lasting at least 20 weeks) and the cumulative proportion of women having live births in the two arms. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT04551807
Study type Interventional
Source JHSPH Center for Clinical Trials
Contact David Shade, JD
Phone 410-955-8175
Email dshade@jhmi.edu
Status Recruiting
Phase Phase 3
Start date September 16, 2020
Completion date September 30, 2024
View Details
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