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Clinical Trial Summary

The object of this study is to assess the intra- and inter-individual variability of apoptosis and autophagy activities in women during pregnancy: 1 / in women with a normal pregnancy and 2 / in pregnant women particularly at risk of complications. The study investigators hypothesize that there would be an intra-trophoblastic dialogue between the mechanisms of autophagy and apoptosis, the promotion of one partially inhibiting the other. The increase in trophoblastic autophagy during pregnancy could thus constitute an anti-apoptosis defense phenomenon, the exhaustion of which would lead to cellular apoptosis and to pathogenic consequences when it devastates the syncytiotrophoblast.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT04443660
Study type Observational
Source Centre Hospitalier Universitaire de Nimes
Contact Sylvie Bouvier
Phone 04.66.68.32.11
Email sylvie.bouvier@chu-nimes.fr
Status Recruiting
Phase
Start date December 30, 2020
Completion date September 2024

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