Pregnancy Related Clinical Trial
Official title:
Endometrial Leucocytes Around the Time of Embryo Implantation in Women Undergoing in Vitro Fertilization- Embryo Transfer (IVF-ET)
Uterine natural killer (uNK) cells have been implicated to play a role in female reproductive performance. Serval studies showed an increased uNK cell density in the endometrium of women with reproductive failure. In this study, we wish to investigate the density and clustering of four different immune cells.
Implantation is a process whereby the embryo attaches itself to the endometrium. In humans,
the endometrium has a specific period of uterine receptivity, which occurs 5-7 days after
ovulation and remains receptive for ~4 days (cycle days 20-24), when embryo implantation
starts. Implantation failure refers to the failure of the embryo to reach a stage when
intrauterine gestational sac is recognized by ultrasonography. It occurs when the embryo is
abnormal or when endometrial function is impaired.
Uterine natural killer (uNK) cells have been implicated to play a role in female reproductive
performance. They comprise 70-80% of the total leukocyte population in the endometrium during
implantation and early pregnancy. Several studies showed an increased uNK cell density in the
endometrium of women with reproductive failure. To better understand the contribution of
various immune factors to endometrial function and future pregnancy, it is proposed to
examine the major immune cells in the same specimen to measure the relative magnitude of the
cell density changes and the degree of clustering between two immune cell types.
The aim of this study is to investigate the endometrial leucocytes profile around the time of
embryo implantation.
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