Stroke Clinical Trial
Official title:
The Acute Effects of Passive Vibration on Cardiovascular Function in Individuals With Stroke
Stroke is the third leading cause of death in the United States. Of those who are affected
by stroke, a third becomes permanently disabled. Risk factors for stroke include, but are
not limited to, advancing age, physical inactivity, arterial stiffness, and most commonly,
high blood pressure. Stroke is a major form of a much boarder problem, cardiovascular
disease (CVD). CVD is considered the primary cause of death in the US. Interestingly,
increased arterial stiffness of elastic arteries (carotid and aorta) has been shown to be
strongly correlated to CVD and stroke. Increased arterial stiffness is considered an
independent risk for the development of CVD and stroke. Hence, arterial stiffness has been
suggested as a potential therapeutic target for CVD and more specifically stroke.
Recently, whole-body vibration (WBV) exercise has been proposed as a new and effective
method to improve muscle mass and muscle strength in younger and older individuals. It is
known that systemic arterial stiffness decreased 40 min after a single WBV session in
healthy men. In our laboratory, we have shown that leg arterial stiffness decreases after a
session of WBV. Taken together, this data seems to suggest WBV may be used as a viable way
to decrease arterial stiffness. Special populations, such as post-stroke patients, may be
unwilling or unable to perform WBV exercise so an inactive form of exercise (vibration)
therapy is needed.
Passive vibration (PV), allows patients to lie in an inactive, supine position, with their
legs placed onto the vibration plate. This exposes the lower limbs to continuous vibration
without performing voluntary muscle contraction. PV has been shown to increase skin blood
flow on the vibrated extremity through vasodilation in healthy individuals and type 2
diabetics. Previous work in our laboratory has demonstrated that a 10-min session of PV on
the legs decreases augmentation index (AIx) , a marker of pressure wave reflection, as well
as leg and systemic PWV through decreases in local peripheral resistance in young men.
However, the effects of PV on arterial function in post-stroke patients are unknown.
It is hypothesized that post-stroke patients will demonstrate a decrease in leg PWV and
central AIx. However, greater responses are expected with the lower vibration frequency.
The purpose of this study is to examine the effects of one acute bout of low and high
frequency passive vibration on blood pressure, heart rate, arterial stiffness, wave
reflection, and autonomic function in post-stroke patients.
The specific aim of this study is:
-To evaluate the effects of an acute bout of both high (40Hz/low amplitude) and low
frequency (25Hz/high amplitude) passive vibration on arterial function and aortic
hemodynamics by assessing blood pressures (systolic, diastolic, mean, pulse pressure),
arterial stiffness (aortic, systemic, leg), aortic wave reflection (augmentation index), and
autonomic function (heart rate variability).
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science
Status | Clinical Trial | Phase | |
---|---|---|---|
Recruiting |
NCT04043052 -
Mobile Technologies and Post-stroke Depression
|
N/A | |
Recruiting |
NCT03869138 -
Alternative Therapies for Improving Physical Function in Individuals With Stroke
|
N/A | |
Completed |
NCT04101695 -
Hemodynamic Response of Anodal Transcranial Direct Current Stimulation Over the Cerebellar Hemisphere in Healthy Subjects
|
N/A | |
Completed |
NCT04034069 -
Effects of Priming Intermittent Theta Burst Stimulation on Upper Limb Motor Recovery After Stroke: A Randomized Controlled Trial
|
N/A | |
Terminated |
NCT03052712 -
Validation and Standardization of a Battery Evaluation of the Socio-emotional Functions in Various Neurological Pathologies
|
N/A | |
Completed |
NCT00391378 -
Cerebral Lesions and Outcome After Cardiac Surgery (CLOCS)
|
N/A | |
Recruiting |
NCT06204744 -
Home-based Arm and Hand Exercise Program for Stroke: A Multisite Trial
|
N/A | |
Active, not recruiting |
NCT06043167 -
Clinimetric Application of FOUR Scale as in Treatment and Rehabilitation of Patients With Acute Cerebral Injury
|
||
Active, not recruiting |
NCT04535479 -
Dry Needling for Spasticity in Stroke
|
N/A | |
Completed |
NCT03985761 -
Utilizing Gaming Mechanics to Optimize Telerehabilitation Adherence in Persons With Stroke
|
N/A | |
Recruiting |
NCT00859885 -
International PFO Consortium
|
N/A | |
Recruiting |
NCT06034119 -
Effects of Voluntary Adjustments During Walking in Participants Post-stroke
|
N/A | |
Completed |
NCT03622411 -
Tablet-based Aphasia Therapy in the Chronic Phase
|
N/A | |
Completed |
NCT01662960 -
Visual Feedback Therapy for Treating Individuals With Hemiparesis Following Stroke
|
N/A | |
Recruiting |
NCT05854485 -
Robot-Aided Assessment and Rehabilitation of Upper Extremity Function After Stroke
|
N/A | |
Active, not recruiting |
NCT05520528 -
Impact of Group Participation on Adults With Aphasia
|
N/A | |
Completed |
NCT03366129 -
Blood-Brain Barrier Disruption in People With White Matter Hyperintensities Who Have Had a Stroke
|
||
Completed |
NCT03281590 -
Stroke and Cerebrovascular Diseases Registry
|
||
Completed |
NCT05805748 -
Serious Game Therapy in Neglect Patients
|
N/A | |
Recruiting |
NCT05621980 -
Finger Movement Training After Stroke
|
N/A |