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Efficacy and Safety Study of Efgartigimod in Adults With Post-COVID-19 POTS — POTS  

Postural Orthostatic Tachycardia Syndrome Clinical Trial

Official title:
A Phase 2 Randomized, Double-blinded, Placebo-controlled Study to Evaluate the Efficacy and Safety of Efgartigimod IV in Adult Patients With Post-COVID-19 Postural Orthostatic Tachycardia Syndrome (POTS)

Clinical Trial Summary

The study aims to investigate the safety, tolerability, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod compared to placebo in participants with post-COVID-19 postural orthostatic tachycardia syndrome (POTS) (post-COVID-19 POTS).

Clinical Trial Description

The study aims to investigate the safety, tolerability, efficacy, pharmacodynamics (PD), pharmacokinetics (PK), and immunogenicity of efgartigimod compared to placebo in participants with post-COVID-19 postural orthostatic tachycardia syndrome (POTS) (post-COVID-19 POTS). Efgartigimod may be a viable treatment option for individuals diagnosed with post-COVID-19 POTS because it has been shown to reduce IgG levels, including IgG autoantibodies, which may underlie some of the autonomic disease manifestations in these patients. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05633407
Study type Interventional
Source argenx
Contact
Status Completed
Phase Phase 2
Start date September 23, 2022
Completion date April 18, 2024
View Details
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