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Effect of Medical Treatment and Prognosis of Postural Orthostatic Tachycardia Syndrome (POTS) — POTS  

Postural Orthostatic Tachycardia Syndrome Clinical Trial

Official title:
Comparison of Effect of Propranolol, Bisoprolol, Pyridosgitmine in Postural Orthostatic Tachycardia Syndrome (POTS) and Prognosis After Medical Treatment

Clinical Trial Summary

The purpose of the study is to investigate effect of medical treatment and prognosis of Postural Orthostatic Tachycardia Syndrome (POTS)

Clinical Trial Description

Many patients who complained of dizziness are eventually diagnosed as POTS. However, the investigation of an appropriate medical treatment of POTS has not been enough yet. Also, the prognosis of the disease after treatment is not well known. It is known that propranolol attenuate the tachycardia and improve symptom burden in patients with POTS. However, the effect of other β-Blocker, bisoprolol compared with propranolol is not known well. In addition, acetylcholinesterase inhibition with pyridostigmine was a effective method of acutely decreasing the tachycardia in patients with POTS. However, difference among three medical treatments effect is not known and long-term studies are not done yet. Therefore, in this study investigator investigate effect of medical treatment (propranolol only, bisoprolol only, propranolol+pyridostigmine, bisoprolol+pyridostigmine) and prognosis of Postural Orthostatic Tachycardia Syndrome.

Longer-term studies are needed to assess this promising therapy. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02171988
Study type Interventional
Source Seoul National University Hospital
Contact
Status Completed
Phase Phase 4
Start date March 2014
Completion date December 2016
View Details
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