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Postpartum Women clinical trials

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NCT ID: NCT06191458 Not yet recruiting - Postpartum Women Clinical Trials

Postpartum Primaquine in Breast Milk

PBC
Start date: May 15, 2024
Phase: Phase 4
Study type: Interventional

Plasmodium vivax and ovale infections both follow chronically relapsing courses, leading to cumulative morbidity and mortality. P. vivax is the second most common malaria worldwide, with an estimated 13.8 million cases annually, and there is increasing concern about severe illness and death in vulnerable populations. Radical cure of P.vivax and P.ovale with 8-aminoquinolines is necessary to prevent relapse. The most widely 8-aminoquinoline is primaquine (7-14 day course), which has been used for almost 75 years. Its widespread use is hampered by the potentially severe haemolysis primaquine may trigger in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common red blood cell enzyme deficiency in the world. Safe administration of primaquine requires at least 30% of normal G6PD activity to avoid significant hemolysis. Screening for malaria is routine in pregnancy, leading to improved detection of P. vivax infections, but primaquine and is contraindicated in pregnancy. As a result, relapses of P. vivax are common in postpartum and lactating women. Normal G6PD activity levels in infants less than 6 months old have only recently been described and have only been established along the Thailand-Myanmar border. Most low-resource settings are therefore unable to determine infant G6PD status. Uncertainty about infant G6PD status means that breastfeeding women are rarely offered radical cure because of theoretical concerns about drug exposure through breast milk triggering haemolysis in breastfed infants and children with G6PD deficiency. Though neonates generally have higher G6PD activity than adults, increased haemolysis for a neonate could theoretically contribute to neonatal jaundice and anaemia. Understanding drug exposure to a breastfeeding neonate is operationally important, as interventions that can be safely offered before women leave the hospital postpartum have higher uptake. Current World Health Organization guidelines advise against prescribing primaquine to lactating women if they are breastfeeding infants less than 6 months old, or breastfeeding infants with G6PD deficiency or unknown G6PD status.

NCT ID: NCT05721625 Not yet recruiting - Postpartum Women Clinical Trials

Comparison of the Effects of Aerobic Exercise and Connective Tissue Massage in Postpartum Women

Start date: February 15, 2023
Phase: N/A
Study type: Interventional

The aim of this study is to compare the effects of aerobic exercise and connective tissue massage on sleep, mother-infant attachment and psychological state in postpartum women.

NCT ID: NCT05465460 Completed - Preterm Birth Clinical Trials

Effect of Banana Blossom on Breast Milk Volume in Mothers of Preterm Newborns

Start date: July 13, 2022
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the effect of banana blossom in increasing breast milk volume

NCT ID: NCT05144269 Completed - Telerehabilitation Clinical Trials

Telerehabilitation in Postpartum Women

Start date: November 30, 2021
Phase: N/A
Study type: Interventional

Postpartum is a transitional period in which physical, social and emotional changes take place in the women. Especially the difficulty of psychological and physiological changes can be associated with deterioration in the women's health. Exercise support programs given to postpartum women have been shown to contribute to physical, mental and social well-being. Statistically significant improvements were found in depression and anxiety symptoms, energy and fatigue parameters, and general health regarding the effects of exercise on mental health in pregnant and postpartum women. The recommendation of the American Association of Obstetricians and Gynecologists (ACOG) is that women start physical activity as soon as they are medically or obstetrically safe. It is stated that they can be included in the exercise programs as soon as possible if it is a normal delivery, and after the 6th week, except for certain exercises if it is a cesarean section. Literature mentioned that exercise studies with postpartum women are insufficient. These mostly focused on the postpartum period and women who had a cesarean section were excluded. In their studies comparing the clinical and virtual environment; Although there is no statistical difference, there are studies showing that it is superior. To the best knowledge, there were no studies on postpartum telerehabilitation. Literature with a multidimensional approach in line with the recommendations of the guidelines were also limited.

NCT ID: NCT04642534 Completed - Clinical trials for Diabetes, Gestational

Circadian Clocks and Eating Patterns (Cohort)

Start date: February 12, 2020
Phase:
Study type: Observational

For women of reproductive age, the overall postpartum weight retention (weight gain between pregnancies) plays a significant role in long-term obesity. With 20% of women retaining ≥ 5 kg at 12 months postpartum, the risk of developing conditions, such as gestational diabetes mellitus (GDM), metabolic syndrome (MS) and subsequently diabetes and cardiovascular diseases, is substantially increased. In post-GDM mothers (women who had GDM in their recent pregnancy), postpartum weight retention is also an essential predictor of future diabetes. Recent studies have identified the impact of circadian rhythms (influencing sleep/wake cycles) and diurnal rhythm of eating (when and how often calories are consumed over a 24h period) on cardio-metabolic disorders. In women, one remarkable feature of the postpartum period is an 'externally imposed' circadian misalignment of both sleep and eating rhythms, because most babies take several weeks to months to establish their daily pattern of activity and feeding, which is particularly relevant for breastfeeding women, as the responsibility is generally on the mother. The overarching goal of this project is to explore the interplay between the diurnal rhythm of eating, circadian and metabolic parameters in humans. The potential postpartum effects of circadian disruption will be unraveled in women who had GDM during their pregnancy and those with an uneventful pregnancy. These women are subject to a circadian misalignment due to their 'externally imposed' changes in sleep/wake cycles and eating times in the postpartum period. With a comprehensive approach combining molecular characterization of in vivo and in vitro circadian clock parameters along with metabolic, endocrine, transcriptomic, and lipidomic studies, the investigators will assess if eating duration and/or circadian misalignment impact on circadian clock parameters of postpartum women in a prospective cohort of 6 months.

NCT ID: NCT04487613 Completed - Postpartum Women Clinical Trials

Effect of Moringa Oleifera Capsule in Increasing Breast Milk Volume in Early Postpartum Patients

Start date: March 15, 2021
Phase: Phase 4
Study type: Interventional

The purpose of this study is to assess the effect of Moringa oleifera leaf capsule in increasing breast milk volume

NCT ID: NCT04337801 Completed - Postpartum Women Clinical Trials

The Effects of Acupressure on Pain After Cesarean Section

Start date: July 15, 2017
Phase: N/A
Study type: Interventional

Purpose: To examine the effect of Pericardium 6 and Large Intestine 4 acupressure on pain and analgesia consumption in women after cesarean section. Methods: This study was conducted in a randomized, single-blind, placebo and control group study design with 132 women, including acupressure (n=44), placebo (n=44), and control (n=44) groups. Acupressure was administered to the Pericardium 6 and Large Intestine 4 points in the second and fourth hours after cesarean section. Data were collected using the personal information form and Visual Analog Scale. This study was used the CONSORT scheme.

NCT ID: NCT04084119 Completed - Postpartum Women Clinical Trials

Effect of Hypopressive Exercise Versus General Strengthening in Postpartum Women

Start date: November 1, 2018
Phase: N/A
Study type: Interventional

The aim of this study is to compare the effect of a hypopressive abdominal exercise program versus a general strengthening exercise program on inter-recti distance, abdominal and lumbar muscle thickness, lumbopelvic and abdominal pain and function, pelvic floor dysfunction, and quality of life in postpartum women. To evaluate the effects of the interventions, the subjects will be assessed at pre-intervention, immediately post-intervention and at 3-months follow-up.

NCT ID: NCT03882086 Completed - Postpartum Women Clinical Trials

Foot Reflexology on Postpartum Sleep Qualıty

Start date: July 1, 2016
Phase: N/A
Study type: Interventional

Aim and objectives: To determine the efficacy of foot reflexology versus standard care for improvement of the sleep quality of postpartum women following vaginal birth. Background: Sleeplessness is one of the major problems experienced by women in the postpartum period following vaginal birth. Design: A single-blind, randomized controlled trial was conducted between July 2016 and March 2017. Methods: In this trial, a total of 54 postpartum women were divided into the intervention group (n= 24) and control group (n= 30). In the intervention group, four sessions foot reflexology was applied for 15 minutes in each foot, every other days between postpartum 14th- 20th day. Measures included daily and nighttime sleep durations and Postpartum Sleep Quality Scale (PSQS) scores. This study was used the CONSORT scheme.

NCT ID: NCT03120208 Recruiting - Clinical trials for Postpartum Depression

Prevalence of Psychological Disorders After Immediate Postpartum Hemorrhage

PSYCHE
Start date: April 27, 2017
Phase: N/A
Study type: Interventional

The objective of this cross-sectional study is to assess the prevalence of depression at 2 months, 6 months, and 1 year postpartum in women who had an immediate postpartum hemorrhage (immediate PPH defined as blood loss ≥ 500 mL within 24 hours of delivery). The potential serious consequences of PPH may lead to a greater number of psychological disorders in these women than in women without PPH.