Effect of Ascorbic Acid Final Flush on Post-operative Pain in Mandibular Molars.

Post Operative Pain Clinical Trial

Official title:

Effect of Ascorbic Acid as a Final Flush on Post-operative Pain After Single Visit Root Canal Treatment for Patients With Symptomatic Irreversible Pulpits Related to Mandibular Molars: Randomized Controlled Trial.

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT05478044
• Other study ID #: ENDO 3 - 7 - 1
• Status: Not yet recruiting
• Phase: N/A
• Start date: August 2022
• Est. completion date: August 2023

Study information

• Verified date: July 2022
• Source: Cairo University
• Contact: Kariman Amin Ismaiel, B.D.S faculty of dentistry
• Phone: +20 1013665586
• Email: kariman.ameen[@]dentistry.cu.edu.eg
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The study is conducted to evaluate the effect of Ascorbic acid as a final flush on post operative pain after single visit root canal treatment in cases with symptomatic irreversible pulpits.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 30
• Est. completion date: August 2023
• Est. primary completion date: August 2023
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Patients above 18 years old and to 60.
• Male or female.
• Patients seeking root canal treatment.
• mandibular molar teeth with symptomatic irreversible pulpits with preoperative acute or moderate pain with hot and cold stimulation with normal periapical radiographic appearance .
• healthy patient (ASA I,II).
• Patient who can understand NRS and sign informed consent.

Exclusion Criteria:

• Medically compromised patients having significant systemic disorders. (ASA III or IV).
• History of intolerance to NSAIDS.
• External root resorption.
• Internal root resorption.
• Vertical root fracture.
• Periapical lesion.
• Pregnancy.
• Use of ibuprofen in the last 12 hour.
• Bleeding disorder.
• Long term corticosteroid use.
• Mobility Grade II or III.
• Pocket depth more than 5mm.
• Previous root canal therapy.
• Non-restorability.
• TMJ problems, bruxism, clenching or traumatic occlusion.
• Inability to perceive the given instructions.

Related Conditions & MeSH terms

• Pain, Postoperative
• Post Operative Pain

Intervention

Drug:
• Ascorbic acid
Ascorbic acid IV ampoules (20%).

Other:
• saline
saline (0.9%)

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Pain intensity measured by numerical rating scale where 0= no pain, 1-3= mild pain, 4-6= moderate pain and 7-10= severe pain.		up to 48 hours after root canal treatment.
Secondary	If there are analgesics taken by the patient after root canal treatment and that will be measured by a questionnaire.		up to 48 hours.