Dextromethorphan for Treatment of Postoperative Pain

Status Recruiting

Clinical Trial Summary

A Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Perioperative Dextromethorphan compared to Placebo for the Treatment of Postoperative Pain

Clinical Trial Description

There is extensive preclinical evidence that dextromethorphan has an analgesic effect in patients with pain of traumatic origin. The primary objective is to of this study is to evaluate the efficacy of perioperative dextromethorphan compared to placebo for postoperative pain in patients undergoing total knee arthroplasty (TKA). This is a single-institution, multi-dose, randomized, placebo-controlled, trial to evaluate the efficacy of perioperative dextromethorphan compared to placebo for postoperative pain in patients undergoing TKA. Male and/or female patients will be randomized to either dextromethorphan treatment group (n = 80) or placebo group (n= 80). Patients will receive 60 mg oral dextromethorphan (or matching placebo) preoperatively, as well as 30 mg 8- and 16-hours postoperatively. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05278494
Study type	Interventional
Source	University of Southern California
Contact	Pui Yan, MS
Phone	323-442-6984
Email	puiyan@med.usc.edu
Status	Recruiting
Phase	N/A
Start date	September 15, 2022
Completion date	December 31, 2025

View Details

See also
Status	Clinical Trial	Phase
Completed	`NCT02489526` - Evaluate the Analgesic Efficacy and Safety of VVZ-149 Injections for Post-Operative Pain Following Colorectal Surgery	Phase 2
Terminated	`NCT05146453` - Sternotomies and PectoIntercostal Fascia Blocks in Fast-Track Cardiac Anesthesiology	Phase 4
Completed	`NCT05635916` - Trial of Liposomal Bupivacaine for TKA	Phase 4
Recruiting	`NCT06028126` - Superficial Parasternal Intercostal Plane Block in Cardiac Surgery Trial	N/A
Not yet recruiting	`NCT03591172` - Using Three Different Final Irrigants and Showing Their Effects on the Success of Revascularization	N/A
Completed	`NCT01686802` - Post-operative Oral Morphine Versus Ibuprofen	Phase 2
Completed	`NCT01667445` - Evaluation of the Use of Spinal Epimorph in Total Knee Arthroplasty	Phase 4
Completed	`NCT01444924` - Transversus Abdominis Plane Blocks for Patients Undergoing Robotic Gynecologic Oncology Surgery	Phase 2
Completed	`NCT00830089` - Trial of a Transversus Abdominis Plane (TAP) Block in Laparoscopic Colorectal Surgery	N/A
Completed	`NCT00968955` - Effect of Local Infiltration Analgesia in Total Hip Arthroplasty	Phase 4
Completed	`NCT00847093` - LMX-4 for Postoperative Pain Management in Infants and Children Undergoing Penoplasty Surgery	Phase 4
Terminated	`NCT00875862` - Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks	Phase 4
Completed	`NCT00390312` - Efficacy and Safety of Intranasal Morphine for Pain After Third Molar Extraction	Phase 2
Recruiting	`NCT05973045` - Investigation of the Effect of Distention Medium Temperature on Image Quality, Hyponatremia Risk, and Post-operative Pain in Operative Hysteroscopy	N/A
Not yet recruiting	`NCT04999670` - Fascial Closure and Post-caesarean Pain	N/A
Enrolling by invitation	`NCT04346407` - Dronabinol for Post-operative Pain After Lumbar Fusion	Phase 4
Completed	`NCT03635515` - Occurrence of Post-op Pain Following Gentlewave	N/A
Terminated	`NCT03201809` - Comparison of Preoperative Ultrasound Guided Pectoralis Nerve Block Placement Versus Intra-operative Placement: A Prospective Randomized Trial	N/A
Completed	`NCT03254056` - Fascial Closure Techniques Post-Operative Pain Laparoscopy	N/A
Not yet recruiting	`NCT02555423` - The Effects of Serratus Plane Block Performed Under Direct Vision on Post-operative Pain in Breast Surgery	N/A