Find the Adequate Dose of Nalbuphine for Laparoscopic Cholecystectomy

Status Not yet recruiting

Clinical Trial Summary

This study evaluate the adequate dose of mutonpain for laparoscopic cholecystectomy in the management of post operative pain. The investigators will randomize patients into three groups to compare the analgesia effects and side effects.

Clinical Trial Description

Nalbuphine is a FDA approved noncontrolled drug of opioid. And it had been applied for post operative pain for different surgeries, claiming that less nausea and vomiting with the same analgesic effect when comparing with morphine.

However, several studies concerning post pain management usually used nalbuphine 0.15-0.3 mg/kg for laparoscopic cholecystectomy. If the analgesic effect of nalbuphine is similar with morphine, less nalbuphine injection could reduce the side effects of opioid.

The investigators will randomize patients into three groups of different initial nalbuphine dose for post laparoscopic cholecystectomy surgical pain, and set patient control analgesia machine with nalbuphine for further pain management. If the pain or side effects of opioid were intolerable, the investigators will change pain medications into NSAIDs or other adequate medications to comfort the patient.

The primary outcome were numerical rating pain score and consumption of nalbuphine. The secondary outcomes were nausea, vomiting, pruritus and satisfactory score, and if any other medications use. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04135534
Study type	Interventional
Source	Kaohsiung Medical University Chung-Ho Memorial Hospital
Contact	Guan-Yu Chen, MD
Phone	88673121101
Email	kindtaco@gmail.com
Status	Not yet recruiting
Phase	N/A
Start date	November 1, 2019
Completion date	December 1, 2020

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