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Post-Dural Puncture Headache clinical trials

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NCT ID: NCT06394024 Completed - Clinical trials for Postdural Puncture Headache

Examination of Postdural Puncture Headache Frequency, Predisposing Factors and Treatment

PDPH
Start date: November 1, 2023
Phase:
Study type: Observational

Post-dural puncture headache (PDPH) is one of the most important complications of neuraxial blocks and lumbar interventions for cerebrospinal fluid (CSF) examination. It occurs due to tear in the dura mater and loss of cerebrospinal fluid (CSF) after intrathecal or epidural interventions.The incidence of PDPH depends on the thickness of the needle used and the type of tip. Headaches are more common with thick needles than with thin needles.In our study, postdural puncture headache in patients whose surgery was planned and spinal anesthesia was applied at Süleyman Demirel University faculty of medicine;frequency, predisposing factors, treatment intended to examine.

NCT ID: NCT06380764 Completed - Clinical trials for Postdural Puncture Headache

Greater Occipital Nerve Block Value in Management of Postdural Puncture Headache

Start date: March 2, 2023
Phase: N/A
Study type: Interventional

Neuraxial techniques are well tolerated and effective options for labor analgesia and anesthesia for caesarean section, and may protect high risk women against severe maternal morbidity. However, neuraxial techniques still have drawbacks especially postdural puncture headache (PDPH) and may be associated with chronic headache, back pain and postnatal depression. PDPH is a relatively common acute complication of neuraxial techniques that was traditionally considered benign and self-limiting, but it significantly impacts patients' general health and quality of life. Greater Occipital Nerve (GON) originates from C2-3 segments and through its muscular relations it is divided as proximal and distal parts; the most proximal part lies between obliquus capitis inferior and semispinalis and then passes through the semispinalis to pierce the trapezius muscle. In distal region of trapezius fascia, the GON is crossed by the occipital artery and exits the trapezius fascia into the nuchal line about 5-cm lateral to midline. Functionally, GON provides motor supplies to the muscles while passing through it and its main sensory supply is in the occipital region.

NCT ID: NCT06272916 Not yet recruiting - Clinical trials for Post-Dural Puncture Headache

Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section.

Start date: March 2024
Phase:
Study type: Observational

This study will be conducted to better comprehend the effect of aminophylline in comparison to magnesium sulphate on preventing and/or treating PDPH.

NCT ID: NCT06271486 Recruiting - Clinical trials for Postdural Puncture Headache

Pregabalin in Treatment of Postdural Puncture Headache

Start date: February 28, 2024
Phase: Phase 3
Study type: Interventional

Lumbar puncture (LP), often known as a "spinal tap," is a standard medical technique pioneered in the late 1900s by Heinrich Quincke. It involves the retrieval and analysis of cerebrospinal fluid (CSF) from the spinal cord, serving as the benchmark for diagnosing conditions like subarachnoid hemorrhage, meningitis, and specific neurological conditions. Pregabalin, an anticonvulsant medicine that blocks calcium entry, is used to treat a variety of diseases. It has been used to relieve pain in a variety of patient groups, including those with chronic pain, epilepsy, and anxiety disorders

NCT ID: NCT06253754 Recruiting - Clinical trials for Post-Dural Puncture Headache

Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache

PDPH
Start date: January 30, 2024
Phase:
Study type: Observational

To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.

NCT ID: NCT06062446 Recruiting - Clinical trials for Post-Lumbar Puncture Headache

A Prospective Study of a Modified Lumbar Puncture (LP) Procedure That Reduces Post-Lumbar Puncture Headaches (PLPH) in Patients

Start date: November 8, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to o determine whether the modified LP procedure reduces the incidence of PLPH to 5% or lower, to determine whether the modified LP procedure reduces the frequency of epidural blood patch (EBP) usage to 10% or lower of the PLPH population and to identify factors that may contribute to or reduce incidence of PLPH

NCT ID: NCT05977361 Not yet recruiting - Clinical trials for Post-Dural Puncture Headache

Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients

ItaREVI
Start date: April 26, 2024
Phase: N/A
Study type: Interventional

Epidural anesthesia represents the most popular method for pain relief during labour. Unintentional dural puncture (UDP) occurs in 0.4-1.5% of labour epidural analgesia, representing therefore the most common complication. Up to 80% of patients with a UDP may develop a post-dural puncture headache (PDPH). When a UDP occurs, two possible strategies have been proposed in order to ensure analgesia during labour: either resiting the epidural catheter in a different intervertebral space, or inserting an intrathecal catheter. Both strategies proved to equally provide analgesia during labour, but their relative contribution in preventing PDPH is still not known. The primary aim of this multicenter randomized controlled trial is therefore to compare these two strategies in the occurrence of PDPH at 24 hours from the UDP.

NCT ID: NCT05969119 Completed - Clinical trials for Postdural Puncture Headache

Addition of Pyridostigmine to Conventional Management of Postdural Puncture Headache

Start date: July 25, 2023
Phase: Phase 4
Study type: Interventional

Postdural puncture headache (PDPH) is a major complication of neuraxial anesthesia that can occur following spinal anesthesia and with inadvertent Dural puncture during epidural anesthesia. The presence of Pyridostigmine in CSF would be expected to increase the level of acetylcholine in CSF and subsequently in the brain through inhibition of cholinesterase. The increased level of acetylcholine would produce cerebral vasoconstriction.

NCT ID: NCT05888324 Recruiting - Clinical trials for Post-Dural Puncture Headache

Factors Associated With the Onset of Chronic Headaches in Patients Who Received a Blood Patch in Post Partum

CHROBLOOD
Start date: June 6, 2023
Phase:
Study type: Observational

The purpose of this study is to identify possible links between conditions for carrying out a blood patch (BP) to treat accidental post dural puncture acute headache (PDPH) in the early post partum period and occurrence of chronic headaches at 1 and 6 months.

NCT ID: NCT05834140 Recruiting - Clinical trials for Cesarean Section Complications

Effects of MET on PPDH, Neck Pain and Disability After Cesarean Section

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to determine the effect of Muscle Energy Techniques on post dural puncture headache, neck pain and disability after Cesarean Section. .