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Post-Dural Puncture Headache clinical trials

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NCT ID: NCT06272916 Not yet recruiting - Clinical trials for Post-Dural Puncture Headache

Comparison of the Effect of Aminophylline, Magnesium Sulphate and Placebo in Prevention of Post Dural Puncture Headache in Parturient Undergoing Caesarean Section.

Start date: March 2024
Phase:
Study type: Observational

This study will be conducted to better comprehend the effect of aminophylline in comparison to magnesium sulphate on preventing and/or treating PDPH.

NCT ID: NCT06271486 Recruiting - Clinical trials for Postdural Puncture Headache

Pregabalin in Treatment of Postdural Puncture Headache

Start date: February 28, 2024
Phase: Phase 3
Study type: Interventional

Lumbar puncture (LP), often known as a "spinal tap," is a standard medical technique pioneered in the late 1900s by Heinrich Quincke. It involves the retrieval and analysis of cerebrospinal fluid (CSF) from the spinal cord, serving as the benchmark for diagnosing conditions like subarachnoid hemorrhage, meningitis, and specific neurological conditions. Pregabalin, an anticonvulsant medicine that blocks calcium entry, is used to treat a variety of diseases. It has been used to relieve pain in a variety of patient groups, including those with chronic pain, epilepsy, and anxiety disorders

NCT ID: NCT06253754 Recruiting - Clinical trials for Post-Dural Puncture Headache

Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache

PDPH
Start date: January 30, 2024
Phase:
Study type: Observational

To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.

NCT ID: NCT06062446 Not yet recruiting - Clinical trials for Post-Lumbar Puncture Headache

A Prospective Study of a Modified Lumbar Puncture (LP) Procedure That Reduces Post-Lumbar Puncture Headaches (PLPH) in Patients

Start date: October 20, 2023
Phase: N/A
Study type: Interventional

The purpose of this study is to o determine whether the modified LP procedure reduces the incidence of PLPH to 5% or lower, to determine whether the modified LP procedure reduces the frequency of epidural blood patch (EBP) usage to 10% or lower of the PLPH population and to identify factors that may contribute to or reduce incidence of PLPH

NCT ID: NCT05977361 Not yet recruiting - Clinical trials for Post-Dural Puncture Headache

Intrathecal Catheter Placement Versus Resiting Epidural Catheter After Dural Puncture in Obstetric Patients

ItaREVI
Start date: April 1, 2024
Phase: N/A
Study type: Interventional

Epidural anesthesia represents the most popular method for pain relief during labour. Unintentional dural puncture (UDP) occurs in 0.4-1.5% of labour epidural analgesia, representing therefore the most common complication. Up to 80% of patients with a UDP may develop a post-dural puncture headache (PDPH). When a UDP occurs, two possible strategies have been proposed in order to ensure analgesia during labour: either resiting the epidural catheter in a different intervertebral space, or inserting an intrathecal catheter. Both strategies proved to equally provide analgesia during labour, but their relative contribution in preventing PDPH is still not known. The primary aim of this multicenter randomized controlled trial is therefore to compare these two strategies in the occurrence of PDPH at 24 hours from the UDP.

NCT ID: NCT05969119 Completed - Clinical trials for Postdural Puncture Headache

Addition of Pyridostigmine to Conventional Management of Postdural Puncture Headache

Start date: July 25, 2023
Phase: Phase 4
Study type: Interventional

Postdural puncture headache (PDPH) is a major complication of neuraxial anesthesia that can occur following spinal anesthesia and with inadvertent Dural puncture during epidural anesthesia. The presence of Pyridostigmine in CSF would be expected to increase the level of acetylcholine in CSF and subsequently in the brain through inhibition of cholinesterase. The increased level of acetylcholine would produce cerebral vasoconstriction.

NCT ID: NCT05888324 Recruiting - Clinical trials for Post-Dural Puncture Headache

Factors Associated With the Onset of Chronic Headaches in Patients Who Received a Blood Patch in Post Partum

CHROBLOOD
Start date: June 6, 2023
Phase:
Study type: Observational

The purpose of this study is to identify possible links between conditions for carrying out a blood patch (BP) to treat accidental post dural puncture acute headache (PDPH) in the early post partum period and occurrence of chronic headaches at 1 and 6 months.

NCT ID: NCT05834140 Recruiting - Clinical trials for Cesarean Section Complications

Effects of MET on PPDH, Neck Pain and Disability After Cesarean Section

Start date: January 1, 2023
Phase: N/A
Study type: Interventional

The goal of this clinical trial is to determine the effect of Muscle Energy Techniques on post dural puncture headache, neck pain and disability after Cesarean Section. .

NCT ID: NCT05804448 Recruiting - Clinical trials for Post-Dural Puncture Headache

Effect of Altitude on Postdural Puncture Headache After Caesarean Delivery

Start date: April 18, 2023
Phase:
Study type: Observational

The aim of this study is to examine the effects of altitude (high altitude versus low altitude) on incidence and severity of postural puncture headache (PDPH) following spinal anaesthesia for caesarean delivery. The investigators hypothesized that the risk of PDPH would be higher in highlander parturients than in lowlander parturients.

NCT ID: NCT05777694 Completed - Pregnancy Related Clinical Trials

Postdural Punction Headache After Ceserian Section

Start date: February 1, 2022
Phase: N/A
Study type: Interventional

The aim of this study is to compare the effect of spinal needle type on postdural puncture headache in patients who will undergo cesarean section. The main question[s] it aims to answer are: [Does spinal needle thickness affect postdural puncture headache?] [What is the response of patients who develop postdural puncture headache to treatment?] In cases accepting cesarean section operation under spinal anesthesia, different tables were used with spinal needles, and it will be questioned whether headache will develop in the first 15 days postoperatively. Postdural puncture headache after surgery will be described.