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NCT05075863 Clinical Trial

Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome

Polycystic Ovary Syndrome Clinical Trial

Official title:
Efficacy of Letrozole Versus Clomiphene Citrate on Ovulation Induction in Patients With Polycystic Ovarian Syndrome

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT05075863
Other study ID # NishtarMU1
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date January 1, 2021
Est. completion date June 30, 2021

Study information
Verified date October 2021
Source Nishtar Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

We aimed this study to determine and compare frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate as published literature shows variations.

Description:

Discrepancy between ovulation induction rate and pregnancy rate is related to anti-estrogenic effects on cervical mucus and endometrium and long acting gonadotrophins are more effective than clomiphene citrate. This study was aimed at comparing frequency of induction of ovulation in women with polycystic ovarian syndrome treated with Letrozole versus clomiphene citrate.

Recruitment information / eligibility
Status Completed
Enrollment 78
Est. completion date June 30, 2021
Est. primary completion date June 30, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group 18 Years to 30 Years
Eligibility Inclusion Criteria: - Diagnosed cases of polycystic ovarian syndrome. Exclusion Criteria: - All women having endocrine disorders like thyroid disorders. - Women having hyperprolactinemia.

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Letrozole
Letrozole as 5mg from day 3 to 7 of menstrual cycle

Locations
Country Name City State
Pakistan Nishtar Medical University Hospital Multan Punjab

Sponsors (1)
Lead Sponsor Collaborator
Nishtar Medical University

Country where clinical trial is conducted

Pakistan, 

Outcome
Type Measure Description Time frame Safety issue
Primary Induction of ovulation was assessed by Transvaginal scan (TVS) Induction of ovulation was assessed by TVS. If follicle of >2cm is found on 12 days TVS and smaller/collapsed on 16 days TVS, ovulation induction was labeled 12 to 16 days.
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