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NCT04838535 Clinical Trial

Follicular Fluid Raman Shifts and IVF Outcomes

Polycystic Ovary Syndrome Clinical Trial

Official title:
The Correlation Between Follicular Fluid Raman Spectrum and Embryo Development in Infertile Patients With Polycystic Ovary Syndrome

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04838535
Other study ID # JIAI E2019-09
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date June 19, 2019
Est. completion date December 19, 2021

Study information
Verified date April 2021
Source ShangHai Ji Ai Genetics & IVF Institute
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study intends to collect about 150 cases of follicular fluid samples from PCOS and non-PCOS infertility patients undergoing in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles (in clinical routines).We tend to detect Raman metabolic profile of the follicular fluid of the PCOS and non-PCOS groups, and find the correlation between the metabolic profile of the follicular fluid of PCOS patients and the oocyte quality, IVF outcome and subsequent embryo development are also under investigation. Metabolomics analysis was applied to look for markers of follicular fluid in PCOS patients, and further exploring data and strategies to improve the embryonic development potential and IVF outcome of PCOS patients.

Recruitment information / eligibility
Status Recruiting
Enrollment 150
Est. completion date December 19, 2021
Est. primary completion date June 19, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender Female
Age group N/A and older
Eligibility Inclusion Criteria: - Patients fit the Rotterdam criteria for PCOS - Patients under IVF cycles Exclusion Criteria: - Patients with male factors infertility - Patients with fallopian tube factors infertility

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Raman spectrum
The wavelength of the follicular fluids were scaned by Raman spectrum

Locations
Country Name City State
China Shanghai JiAi Genetics and IVF Institute Shanghai Shanghai

Sponsors (1)
Lead Sponsor Collaborator
ShangHai Ji Ai Genetics & IVF Institute

Country where clinical trial is conducted

China, 

Outcome
Type Measure Description Time frame Safety issue
Primary Difference between polycystic ovary syndrome and normal follicular fluids Raman spectrum was applied and the Raman spectrum characteristic absorption peak can be revealed. PCA analysis was used to measure the degree of differential shifts. 24 months
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