Insulin Resistance Clinical Trial
Official title:
MicroRNA as Biomarkers for Development of Metabolic Syndrome in Women With Polycystic Ovary Syndrome
The aim of this study is to explore the microRNA profile in serum of women with Polycystic Ovary Syndrome and investigate the correlation between the microRNA profile and markers of metabolic syndrome.
The study consist of 2 parts:
1. A cross-sectional study of a cohort of women with PCOS with analysis of materials from
the established biobank. (the PICOLO cohort) Data and blood samples from 266 women with
PCOS was collected from January 2010 - February 2013 as a part of the PICOLO
collaboration: "PCOS, infertility, Cardiovascular and Obstetric risk markers and
Long-term Outcome" at Holbaek Fertility Clinic and at Herlev Hospital.
Serum samples will be analysed with Reverse Transcript polymerase chain Reaction
(RT-qPCR) for selected microRNAs.
2. A follow-up study of local participants from the PICOLO study. 90 of the participants
were recruited at Holbaek Fertility Clinic.
Following tests will be performed at reexamination, in order to describe the clinical
phenotype: Health interview, anthropometrics, acne score, Ferriman-Gallway score, blood
pressure, Transvaginal ultrasound of uterus and ovaries, insulin Resistance (IR) assessed
with Oral glucose Tolerance test (OGTT), Venous blood for hormone analysis and lipid status.
MicroRNA analysis with Taqman microRNA array will be performed on serum samples.
Detection and treatment of women with PCOS is a challenge due to the variability of the
syndrome. If MiRNA could serve as marker of metabolic syndrome, it would be possible to
detect and follow the women of greater risk at an earlier stage, and thereby preventing
morbidity.
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