Chronic Periodontitis and Polycystic Ovary Syndrome

Polycystic Ovary Syndrome Clinical Trial

Official title:

Evaluation Of Lipid Peroxidation, Oxidative DNA Damage And Total Antioxidant Status In Patients With Periodontitis And Polycystic Ovary Syndrome: A Cross Sectional Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02954120
• Other study ID #: PCOSandCP
• Status: Completed
• Start date: May 2013
• Est. completion date: September 2015

Study information

• Verified date: January 2020
• Source: Bezmialem Vakif University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals.

Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.

Description:

RESULTS:

Salivary 8-OHdG levels in the PCOSCP and CP groups were statistically higher than those in both the PCOSPH and the PH groups (P < 0.05). There was no statistical difference between the PCOSCP, CP, and PCOSPH groups with regard to salivary MDA and TAS levels (P > 0.05). Highest serum 8-OHdG and MDA levels and lowest serum TAS levels were seen in the PCOSCP group (P < 0.05). Serum 8-OHdG and MDA levels in the PCOSPH group were higher than those in both systemically healthy groups (PH and CP) (P < 0.05). Salivary TAS levels were highest (P < 0.05) in the PH group. There was no statistical difference between the CP and PCOSPH groups, but serum TAS levels were lower than those in the PH group (P < 0.05).

CONCLUSIONS:

CP, which led to an increase in serum and salivary 8-OHdG and MDA levels and a decrease in serum TAS levels in patients with PCOS, contributed to increased OS. This effect was more prominent in serum levels than in salivary levels.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 88
• Est. completion date: September 2015
• Est. primary completion date: May 2015
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Newly diagnosed non-obese PCOS patients

• Never smokers

• Had no history of systemic disease

• BMI<25 kg/m2

• Participants had =20 teeth present.

Exclusion Criteria:

• Pregnancy

• Lactation

• Hemoglobin A1c (HbA1c) = 6.5%

• 2-h oral glucose tolerance test (OGTT-2h) =200

• Cushing syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid dysfunction, and androgen-secreting tumors

• Any drug use within the past 6 months

• Periodontal treatment within the past 6 months

Related Conditions & MeSH terms

• Chronic Periodontitis
• Periodontitis
• Polycystic Ovary Syndrome
• Syndrome

Intervention

Other:
• no intervention provided

Locations

Country	Name	City	State
Turkey	Department of Periodontics, Faculty of Dentistry, Bezmialem Vakif University	Istanbul	Fatih

Sponsors (1)

Lead Sponsor	Collaborator
Bezmialem Vakif University

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	8-OHdG levels (nanogram per mililiter(ng/mL))	by ELISA test	appoximately 2 years
Primary	MDA levels (micromole per liter (µmol/L))	by ELISA test	appoximately 2 years
Primary	TAS levels (millimolar per liter (mmol /L))	by ELISA test	appoximately 2 years
Primary	Plaque Index (PI)	Silnes-Löe Periodondal Index	appoximately 2 years
Primary	Gingival Index (GI)	Löe-Silness Periodontal Index	appoximately 2 years
Primary	Bleeding on probing (BOP)	GIngival Bleeding Index	appoximately 2 years
Primary	Clinical attachment level (CAL)	by measuring the distance between the cementoenamel junction and the periodontal pocket base	Patients were seen one time
Primary	Probing pocket depth (PD))	distance between free gingival margin and periodontal pocket base by usin periodontal probe	appoximately 2 years
Secondary	number of individuals with chronic periodontitis	individuals in the group	appoximately 2 years
Secondary	numberer of individuals with polycystic ovary syndrome	individuals in the group	appoximately 2 years